valproic acid
information and resources from the National Cancer Institute
NCI Thesaurus | valproic acid
A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. NCI Thesaurus | valproic acid
A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis.
|
|
|
|
news articles
Valproic acid may help slow the progression of dementia Mar 14, 2006
News-Medical.net, Patients were randomized to receive either 250 milligrams of valproic acid, or placebo, twice daily. Valproic acid is commonly used ...
Genes And Environment Interact To Promote Cancer Mar 31, 2006
Medical News Today (press release), In 2004, Duke researchers showed that an industrial solvent (EGME) and a commonly prescribed drug, Valproic acid, potently boosted estrogen and progestin ...
Antiseizure drug may treat HIV-related dementia Mar 28, 2006
The Advocate, Valproic acid, an antiseizure drug, has shown promise in treating HIV-related dementia, reports the Omaha World-Herald. A safety ...
German Cancer Award 2006 For Martin Göttlicher Mar 22, 2006
Medical News Today (press release), The knowledge that a drug used as an antilepileptic agent, valproic acid, has teratogenic side effect, ie it damages embryos in their development, was the ...
Researchers' findings advance leukemia research Mar 23, 2006
Therapeutics Daily (subscription) (press release), ...leukemia data. Study 1: Valproic acid (VPA) was deemed clinically useful in low-risk myelodysplastic syndrome (MDS). According to ...
D-Pharm's DP-VPA shown to be well-tolerated for resistant epilepsy ... Mar 27, 2006
Therapeutics Daily (subscription) (press release), ...announced publication of preclinical and clinical results obtained with DP-VPA, D-Pharm's proprietary lipid modified version of valproic acid (VPA) that ...
New hope for HIV dementia Mar 15, 2006
myDNA.com, ...and six without. Patients were randomized and twice daily received either 250 milligrams of valproic acid or a placebo. "The most ...
Common Anticonvulsant May Help Slow Progression of Dementia Mar 10, 2006
Newswise (press release) ...impairment, six without. Patients were randomized to receive either 250 milligrams of valproic acid, or placebo, twice daily. "The most ...
Acupuncture, Real or Sham, Equals Drug Treatment for Migraine Mar 3, 2006
CNN ...or continuous drug prophylaxis. Drugs included beta-blockers, Sibelium (flunarizine), and valproic acid. The primary outcomes after ...
HepaLife to Accelerate Research Activities and Bolster Management ... Mar 9, 2006
Genetic Engineering News, ...childhood DILI include acetaminophen; the group of anti-epileptics including phenytoin, carbamazepine, andphenobarbital; valproic acid; sulfonamides; pemoline ...
Repligen commences phase 2 trial of RG2417 for bipolar depression Mar 9, 2006
News-Medical.net, Although lithium and anticonvulsants such as valproic acid have substantially improved the prognosis of bipolar disorder, many individuals are unable to ...
Use of Intravenous Valproate in a Patient With Neuroleptic ... Mar 8, 2006
Journal of Neuropsychiatry (subscription) Kruger S, Braunig P: Intravenous valproic acid in the treatment of severe catatonia J Neuropsychiatry Clin Neurosci. 2001; 13(2):303-304. ...
Trimipramine for Refractory Panic Attacks Mar 2, 2006
Am J Psychiatry (subscription) ...bupropion, amoxapine, fluoxetine, sertraline, citalopram, paroxetine, fluvoxamine, duloxetine, escitalopram, carbamazepine, valproic acid, lithium, olanzapine ...
Restless legs or shaky legs: Conditions incongruent Mar 5, 2006
Fort Wayne Journal Gazette, ...the population. Anticonvulsant medications such as valproic acid (Depakote) and gabapentin (Neurontin) can provide some relief. In ...
Acupuncture Similar to Drug Treatment for Prevention of Migraine Mar 1, 2006
Medscape (subscription) ...inserted. The remaining 187 patients were randomly assigned to drug treatment -- beta-blockers, flunarizine, or valproic acid. All ...
D-Pharm Announces the Second Recommendation of an Independent ... Mar 7, 2006
PR Newswire UK (press release), In addition to DP-b99 D-Pharm's pipeline includes DP-VPA, a new chemical entity that is a targeted modification of valproic acid for epilepsy, bipolar disorder ...
Positive Results Published for D-Pharm's DP-VPA in Epilepsy Feb 28, 2006
PharmaLive.com (press release), ...announced today publication of preclinical and clinical results obtained with DP-VPA, D-Pharm's proprietary lipid modified version of valproic acid (VPA). ...
ENCEPHALOPATHY AND HYPERAMMONEMIA ASSOCIATED WITH VALPROIC ACID Dec 7, 2005
The Journal of Pharmacy Technology OBJECTIVE: To discuss the case of a patient who experienced an altered level of consciousness secondary to hyperammonemia associated with valproic acid who had ...
Valproic acid (Depakote) may help treat lupus Nov 20, 2005
News-Medical.net, The drug, valproic acid (Depakote), prevents skin disease and reduces the severity of kidney disease in a mouse model of lupus, said Nilamadhab Mishra, MD, a ...
Abbott's Depakote ER (Divalproex Sodium Extended-Release Tablets) ... Dec 7, 2005
DG News Hepatic failure resulting in fatalities has occurred in patients receiving valproic acid and its derivatives, usually during the first six months of treatment. ...
Dacogen(TM) (Decitabine) Injection Data Presented at American ... Dec 12, 2005
Genetic Engineering News, ...of a Phase I/II Study of the Combination of the Hypomethylating Agent 5-aza-2'-Deoxycytidine (DAC) and the Histone Deacetylase Inhibitor Valproic Acid (VPA) in ...
Epilepsy Drug Could Fight Lupus Nov 17, 2005
ABC News THURSDAY, Nov. 17 (HealthDay News) — The common anti-seizure drug valproic acid may also prove effective for treating lupus patients, researchers report. ...
Oxcarbazepine Effective in Pediatric Nocturnal Frontal Lobe ... Dec 9, 2005
DG News ...of NFLE was made, the children, whose ages ranged from 4 to 13, were started on antiepileptic drugs other than OXC (phenytoin, valproic acid, gabapentin, and ...
Source: Pharmion Corporation Dec 8, 2005
Yahoo! News (press release) 2527 Lewis R. Silverman, MD and CALGB Poster #: 731 Time: Sunday, December 11, 6:00 - 7:30 pm Sequential Treatment with 5-Azacytidine, Valproic Acid (VPA), and ...
BLACK BOX WARNINGS OFTEN GO UNHEEDED Nov 22, 2005
National Center for Policy Analysis, For example, valproic acid -- a treatment for epileptic seizures, migraines and bipolar disorder -- includes a black-box warning about liver toxicity that ...
Health & Medicine Nov 19, 2005
U.S. News & World Report Some 30 percent of people who took valproic acid for epilepsy, for example, weren't getting routine blood tests for liver damage. ...
Doctors often ignore 'black box' warnings on prescription drugs Nov 18, 2005
U.S. News & World Report But of those people prescribed valproic acid for epilepsy, for example, some 30 percent weren't getting routine blood tests to test for liver damage as the ...
ADHD and Comorbid Medical and Psychiatric Disorders Dec 1, 2005
Medscape (subscription) A recent double-blind study of valproic acid (VPA) found that Young Mania Rating Scale scores of children who received VPA plus a mixed amphetamine salt (MAS ...
|
|
