tipifarnib

tipifarnib information and resources from the National Cancer Institute

tipifarnib

A nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis.tipifarnib

A nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis.

Responses Similar with Letrozole and Tipifarnib in Breast Cancer ... Dec 16, 2005
DG News ...in response among breast cancer patients when they were treated with letrozole with or without the investigative farnesyltransferase inhibitor tipifarnib. ...

Keryx Biopharmaceuticals, Inc. Announces Oral Presentation on KRX ... Dec 8, 2005
PR Newswire (press release), These abstracts include: * 1488 Combination of Farnesyl Transferase Inhibitor (Tipifarnib) with Perifosine Induces Apoptosis through phos-PDK1 in Human ...

Keryx Biopharmaceuticals, Inc. Announces Oral Presentation on KRX ... Dec 8, 2005
PharmaLive.com (press release), 1488 Combination of Farnesyl Transferase Inhibitor (Tipifarnib) with Perifosine Induces Apoptosis through phos-PDK1 in Human Lymphoma and Leukemia Cell Lines. ...

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