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thioguanine
thioguanine
information and resources from the National Cancer Institute
thioguanine
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis.
thioguanine, 6-TG GlaxoSmithKline Jan 18 1966
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thioguanine
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