tamoxifen citrate
information and resources from the National Cancer Institute
NCI Thesaurus | tamoxifen citrate
The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. NCI Thesaurus | tamoxifen citrate
The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth.
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news articles
Select AIDS, cancer drugs to become cheaper Mar 2, 2006
Sify, ...revision are cisplatin, cytosine arabinoside, danazol, daunorubicin HCL, etoposide, flutamide, ondansetron, pacitaxel, tamoxifen citrate, vinblastine sulphate ...
ARIMIDEX (anastrozole) Featured in Studies Evaluating Impact of ... Dec 9, 2005
PharmaLive.com (press release), NOLVADEX(R) (tamoxifen citrate) is approved for the adjuvant treatment of node-positive and node-negative early breast cancer in postmenopausal women following ...
AstraZeneca Provides Additional Support to Hurricane Victims Nov 17, 2005
PR Newswire (press release), EMLA Cream (lidocaine 2.5% and prilocaine 2.5%), FASLODEX(R) (fulvestrant), NEXIUM(R) (esomeprazole magnesium), NOLVADEX(R) (tamoxifen citrate), PLENDIL(R ...
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