talotrexin
information and resources from the National Cancer Institute
NCI Thesaurus | talotrexin
An antimetabolite analog of aminopterin with antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance. NCI Thesaurus | talotrexin
An antimetabolite analog of aminopterin with antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance.
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news articles
Hana begins second stage study of Talotrexin 01 Apr 2006
Pharmaceutical Business Review San Francisco-based firm Hana Biosciences has initiated a multinational phase II clinical trial of Talotrexin in relapsed or refractory non-small cell lung ...
Hana Biosciences FY05 Loss/Share Narrows - Quick Facts Mar 16, 2006
Trading Markets, It also plans to initiate Talotrexin Ph II NSCLC, with potential interim results in fourth quarter of 2006, in first half of 2006.
Hana Biosciences Reports 2005 Results from Operations Mar 16, 2006
Genetic Engineering News, Hana plans to submit a New Drug Application (NDA) to the FDA for Zensana(TM) in 2006, with a targeted commercial launch in 2007. -- Talotrexin (PT-523) is a ...
Hana Biosciences Reports Third Quarter Results Dec 14, 2005
Genetic Engineering News, Talotrexin (PT-523) commenced a multinational, multicenter phase I/II clinical trial in non-small cell lung cancer (NSCLC). The ...
Hana Biosciences Announces Changes to Strengthen Management Team Dec 16, 2005
Business Wire (press release), ...to senior vice president, chief medical officer and will assume the overall leadership of the company's development pipeline including Talotrexin (PT-523 ...
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