sargramostim
information and resources from the National Cancer Institute
NCI Thesaurus | sargramostim
A recombinant therapeutic agent which is chemically identical to or similar to endogenous human GM-CSF. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity. NCI Thesaurus | sargramostim
A recombinant therapeutic agent which is chemically identical to or similar to endogenous human GM-CSF. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity.
Prokine Immunex Corp Nov 07 1996
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news articles
Vaccine and Antibody Treatment of Prostate Cancer Mar 22, 2006
Community Dispatch (press release) ...fixed dose of vaccine vectors containing PSA and three human costimulatory molecules (ICAM, LFA-3 and B7.1; designated TRICOM) and sargramostim, and sequential ...
New Data Suggest Novel Low-dose Outpatient Chemobiotherapy Regimen ... Dec 12, 2005
PR Newswire (press release), ...chemobiotherapy combination of temozolomide, the granulocyte macrophage colony stimulating factor (GM-CSF) LEUKINE(R) (sargramostim), Interferon-alpha-2b and ...
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