pravastatin
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NCI Thesaurus | pravastatin
A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. NCI Thesaurus | pravastatin
A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.
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news articles
As cheap statins arrive, why fret about lifestyle? Mar 31, 2006
MSNBC But many physicians are wary of what might happen when the blockbuster cholesterol-lowering drugs pravastatin and simvastatin, which go by the brand names ...
Data advance knowledge in statins research Mar 31, 2006
Therapeutics Daily (subscription) (press release), Outcomes data from more recent trials involving atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin, have since expanded the patient population ...
CRP Levels Increase After Statin Withdrawal Mar 15, 2006
Medscape (subscription) To fill in the knowledge gap, his team evaluated the effects of withdrawal from pravastatin, 40 mg, on CRP levels in 566 patients participating in the ...
Teva Pharmaceuticals Industries "overweight," estimates raised Mar 27, 2006
newratings.com Teva Pharmaceuticals Industries' earnings in 2006 are expected to be boosted by the launch of generic pravastatin during April, the analyst adds. ...
Treatment of hypercholesterolemia in patients with the metabolic ... Mar 15, 2006
Nature.com (subscription), Stender S et al. (2005) Comparison of rosuvastatin with atorvastatin, simvastatin and pravastatin in achieving cholesterol goals and improving plasma lipids in ...
Bentley Pharmaceuticals Provides Update on Product Approvals ... Feb 27, 2006
Genetic Engineering News, ...in Spain for various dosage forms of citalopram (generic version of Celexa(R)), finasteride (generic version of Proscar(R)) and pravastatin (generic version of ...
Bentley Pharmaceuticals Provides Update on Product Approvals ... Feb 27, 2006
Finanzen.net, ...in Spain for various dosage formsof citalopram (generic version of Celexa(R)), finasteride (genericversion of Proscar(R)) and pravastatin (generic version ...
Can a Potent Statin Actually Regress Coronary Atherosclerosis? Mar 13, 2006
Journal of American Medical Association (subscription), 5 The choice of simvastatin would have been a good one because it is significantly more potent than pravastatin, which was used in the REVERSAL trial 3 and in ...
Maintenance therapies offer lasting heart health benefits Mar 14, 2006
EurekAlert (press release), A total of 566 patients who received pravastatin therapy were evaluated in the study, during which investigators measured CRP levels at baseline, after four ...
Drug may cut artery plaque Mar 17, 2006
Baltimore Sun, ...class. Others include ovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor) and atorvastatin (Lipitor). AstraZeneca ...
Bentley announces score of Spanish generics approvals Feb 28, 2006
Pharmaceutical Business Review In addition, Laboratorios Rimafar and Laboratorios Belmac each received approvals to market generic-equivalent and branded versions of pravastatin in 10mg ...
Teva’s complete victory Mar 20, 2006
Globes, ...that the “United States Court of Appeals for the District of Columbia had vacated the FDA's determination that Teva's exclusivity on pravastatin 10, 20, and ...
Bentley Pharmaceuticals gets 12 product dosage approvals in Spain Mar 23, 2006
Therapeutics Daily (subscription) (press release), ...in Spain for various dosage forms of citalopram (generic version of Celexa), finasteride (generic version of Proscar) and pravastatin (generic version of ...
Teva Pravachol Decision Sent Back to FDA Mar 16, 2006
MSN Money ...based Teva received a letter from the FDA saying the company's 180 days of marketing exclusivity for three different strengths of pravastatin, the active ...
88% Of GPs in the UK Prefer Physical Exercise or Diet as the ... Mar 15, 2006
Genetic Engineering News, ...widely prescribed drugs for constituents of the metabolic syndrome (eg, metformin, glibenclamide, simvastatin, lovastatin, pravastatin, ramipril, amlodipine ...
Inflammatory Marker Rebounds After Statin Withdrawal: Presented at ... Mar 14, 2006
DG News In the prospective double blind placebo controlled trial, the researchers examined the effects of withdrawal after 4 years of 40 mg pravastatin therapy in 566 ...
New tests for heart disease Mar 15, 2006
ITP.net, An unrelated analysis of data from a trial of cholesterol-lowering statins showed that treatment with pravastatin (Pravachol) was more effective in people with ...
How can I prevent my children from becoming travel sick? Mar 2, 2006
Times Online, Lipostat (pravastatin) is another statin that can be taken with grapefruit juice. Crestor is a very effective statin, relatively recently introduced. ...
Drug pravastatin may provide a previously unknown cardiovascular ... Nov 20, 2005
News-Medical.net, The drug pravastatin, which is used widely to decrease high cholesterol, may provide a previously unknown cardiovascular benefit in addition to lowering lipids ...
Lipitor Free from Generic Competition Until 2011 Dec 18, 2005
SeniorJournal.com, Nov. 16, 2005 - The drug pravastatin, which is used widely to decrease high cholesterol, may provide a previously unknown cardiovascular benefit in addition to ...
Ranbaxy to launch 30 new drugs in the US Nov 24, 2005
siliconindia.com, Among the seven products from the first to file pipeline, which are to be launched, are Pravastatin, Siimvastatin and Modanifil, which have a combined current ...
Bristol-Myers Squibb: $1 billion cost savings by 2008 Dec 14, 2005
Pharmaceutical Business Review ...revenues have been suffering from high levels of generic competition against its key products, including one of its biggest earners, Pravachol (pravastatin). ...
Ranbaxy plans to launch 15 products in US Nov 18, 2005
Sify, Among 7 products with "first-to-file" marketing status, which will give it exclusive marketing rights for a few months, are cholesterol drugs Pravastatin 80 mg ...
Matrix to buy 55% in Concord Bio Dec 6, 2005
Business Standard, ...the European Department for Quality Medicines. DMFs for mycophenolate mofetil and pravastatin will be filed in the next quarter.
B-MS moves again to cut spending Dec 13, 2005
Pharma Times (subscription), ...the group will face what is likely to be its final significant generic challenge until 2011, as the cholesterol-buster Pravachol (pravastatin sodium) looses ...
When drugs, grapefruit interact Dec 12, 2005
Charleston Post Courier (subscription), But if you don't want to give up your grapefruit, you might talk to your doctor about switching to a different cholesterol-lowering drug, pravastatin (Pravachol ...
Fatty Acids May Protect against Cardiovascular Disease: Presented ... Nov 21, 2005
DG News In the Japan EPA Lipid Intervention Study (JELIS), researchers randomized 18,645 men and women who were taking pravastatin or simvastatin for ...
Significant Decision Gives Patients Better Access to Heart Disease ... Dec 2, 2005
PR Newswire (press release), Relations of lipoprotein subclass levels and low-density lipoprotein size to progression of coronary artery disease in the pravastatin limitation of ...
Scottish researcher discovers HDL cholesterol predicts the ... Nov 27, 2005
Newstarget.com, ...treated," he said. The study used a single drug, pravastatin (Pravachol), but the results probably apply to all statins, Packard said.
Pharma Reformulates Dec 5, 2005
Chemical & Engineering News Express Scripts has removed Lipitor (atorvastatin) from its preferred 2006 drug list ahead of the arrival of generic simvastatin and pravastatin, meaning that ...
Children's hospital to participate in study of single nucleotide ... Nov 20, 2005
TMCnet ...carried out by investigators in PARC and other research programs that have tested effects of the statin drugs simvastatin, pravastatin, rosuvastatin and ...
AHA: Fish Oil Plus Statin Reduces Coronary Events Nov 18, 2005
CNN ...of coronary disease who took 1,800 mg/day of highly purified eicosapentaenoic acid (EPA) together with statin therapy-either Pravachol (pravastatin) or Zocor ...
Analyst Meet Nov 18, 2005
India Infoline.com, Major FTF opportunities would be Pravastatin, Simvastatin and Modafinil. The company now has a strong distribution channels in the US with 20 retail chains. ...
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