mycophenolate mofetil
information and resources from the National Cancer Institute
NCI Thesaurus | mycophenolate mofetil
The morpholinoethyl ester of mycophenolic acid (MPA) with potent immunosuppressive properties. Mycophenolate stops T-cell and B-cell proliferation through selective inhibition of the de novo pathway of purine biosynthesis. In vivo, the active metabolite, MPA, reversibly inhibits inosine 5'-monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of guanine nucleotides. MPA displays high lymphocyte specificity and cytotoxicity due to the higher dependence of activated lymphocytes on both salvage and de novo synthesis of guanine nucleotides relative to other cell types. NCI Thesaurus | mycophenolate mofetil
The morpholinoethyl ester of mycophenolic acid (MPA) with potent immunosuppressive properties. Mycophenolate stops T-cell and B-cell proliferation through selective inhibition of the de novo pathway of purine biosynthesis. In vivo, the active metabolite, MPA, reversibly inhibits inosine 5'-monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of guanine nucleotides. MPA displays high lymphocyte specificity and cytotoxicity due to the higher dependence of activated lymphocytes on both salvage and de novo synthesis of guanine nucleotides relative to other cell types.
|
|
|
|
news articles
Astellas Receives FDA Approval of Prograf(R) (Tacrolimus) for Use ... 01 Apr 2006
PR Newswire (press release), In a 3-arm study conducted in the US, 331 patients received corticosteroids and Prograf plus sirolimus, Prograf plus mycophenolate mofetil (MMF) or ...
Aspreva Announces Completion of Patient Enrolment in Phase III ... Mar 30, 2006
CNW Telbec (Communiqués de presse), The study is designed to assess the safety and efficacy of CellCept(R) (mycophenolate mofetil) in association with corticosteroids to achieve remission in ...
New treatments show promise for some diabetics Mar 7, 2006
Pittsburgh Post Gazette, ...as Type 1 Diabetes Trialnet, patients diagnosed with diabetes within the past three months are given two immunosuppressant drugs: Mycophenolate mofetil, or MMF ...
Mycophenolate mofetil may be more effective in inducing lupus ... Nov 24, 2005
RxPG NEWS, Carolina at Chapel Hill School of Medicine, Treating lupus patients suffering from kidney inflammation with a medicine known as mycophenolate mofetil may be ...
Mycophenolate Mofetil - Clinical trial supports better treatment ... Nov 25, 2005
Medical News Today (press release), Treating lupus patients suffering from kidney inflammation with a medicine known as mycophenolate mofetil may be more effective in inducing remission than ...
Lupus nephritis, Mycophenolate Mofetil may be more effective in ... Dec 1, 2005
Xagena.it, In lupus patients suffering from kidney inflammation Mycophenolate Mofetil ( CellCept ) may be more effective in inducing remission than standard regimen of ...
Clinical Trial of New Drug Offers Hope to Lupus Patients Nov 28, 2005
Newsinferno.com, ...of Medicine reveals that lupus patients suffering from kidney inflammation, or nephritis, may benefit more from a drug called mycophenolate mofetil than from ...
Kidney Transplant Drug May Help Lupus Nov 28, 2005
KSDK, It's called "mycophenolate mofetil" and researchers say it could be more effective in inducing remission than treating patients with the standard regimen of ...
Matrix to buy 55% in Concord Bio Dec 6, 2005
Business Standard, ...the European Department for Quality Medicines. DMFs for mycophenolate mofetil and pravastatin will be filed in the next quarter.
Teva Pharmaceutical Gets $350M Facility and Crucell Announces PER. ... Nov 25, 2005
Financial News USA (press release), ...reported that the results of Dr. Ellen M. Ginzler's investigator initiated trial (IIT) comparing orally administered mycophenolate mofetil (CellCept®) to ...
Results of Investigator Initiated Trial of CellCept in Lupus ... Nov 25, 2005
PR Newswire (press release), ...today reported that the results of Dr. Ellen M. Ginzler's investigator initiated trial (IIT) comparing orally administered mycophenolate mofetil (CellCept(R ...
Roche drug helps lupus-linked kidney problems Nov 23, 2005
Reuters AlertNet, CellCept, also known as mycophenolate mofetil, produced some mild nausea or diarrhea but "not a single patient dropped out of the study because those side ...
Drug Fights Lupus-Linked Kidney Disease Nov 23, 2005
Forbes ...known as lupus kidney disease. The drug is mycophenolate mofetil (MMF), marketed as CellCept by drug maker Roche. If approved by the ...
Drug shows promise in lupus patients Nov 30, 2005
Newsday, When the kidneys are relentlessly bombarded, they can fail. The drug producing new hope is called MMF (mycophenolate mofetil), which is taken in pill form. ...
Source: Lupus Foundation of America Nov 23, 2005
Yahoo! News (press release) 23 /PRNewswire/ -- "We applaud the results of a research study on the effectiveness of mycophenolate mofetil (MMF) as a potential new treatment for lupus ...
Research Published in The New England Journal of Medicine ... Nov 23, 2005
Yahoo! News (press release) A study published in the New England Journal of Medicine (NEJM) this week shows promising results of the use of mycophenolate mofetil (MMF), an ...
Statement from Sandra Raymond, President and CEO, Lupus Foundation ... Nov 23, 2005
EurekAlert (press release), ..."We applaud the results of a research study on the effectiveness of mycophenolate mofetil (MMF) as a potential new treatment for lupus nephritis (lupus kidney ...
Study: Drug Shows Promise In Lupus Patients Nov 23, 2005
WBAL Channel.com, CellCept, with a generic name of mycophenolate mofetil, is an immunosuppressive drug used to combat organ rejection in transplant patients. ...
Standard of care for lupus is challenged Nov 23, 2005
United Press International Center in Brooklyn, NY, say their have obtained promising results for patients suffering from lupus nephritis from the use of mycophenolate mofetil, or MMF, an ...
New drug CellCept far more effective in treating kidney problems ... Nov 24, 2005
News-Medical.net, Ginzler says that CellCept, which is also known as mycophenolate mofetil, did cause some mild nausea or diarrhea but no patient dropped out of the study ...
BioCryst Out-Licenses BCX-4208 To Roche In Potential $560M Deal Nov 30, 2005
BioWorld Online (subscription), In transplantation, it could follow a path already blazed by Roche's Cellcept (mycophenolate mofetil), which Riggs said loses patent protection in five years. ...
ACR: Lupus Prognoses Improve With Better Use of Standard Therapies Nov 21, 2005
MedPage Today, ...and other immunosuppressive and cytotoxic drugs, such as Imuran (azathioprine), Cytoxan (cyclophosphamide), methotrexate, and Cellcept (mycophenolate mofetil). ...
Aspreva Announces Completion of Patient Enrolment in Phase III ... Nov 28, 2005
PR Newswire (press release), ...today announced completion of enrolment of 176 patients in the phase III clinical study to assess the safety and efficacy of mycophenolate mofetil (MMF or ...
Drug treats lupus kidney disease Nov 28, 2005
myDNA.com, A study published in the New England Journal of Medicine this week shows promising results of the use of mycophenolate mofetil (MMF), an immunosuppressive drug ...
|
|
