lovastatin
information and resources from the National Cancer Institute
NCI Thesaurus | lovastatin
A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering activity and potential antineoplastic activity. Lovastatin is hydrolyszed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in the cholesterol biosynthesis. In addition, this agent may inhibit tumor cell proliferation and reduce tumor cell invasiveness, thereby decreasing tumor metastatic potential; induce tumor cell apoptosis, possibly by inhibiting protein geranylgeranylation and; arrest cells in the G1 phase of the cell cycle, an effect that sensitizes tumor cells to the cytotoxic effects of ionizing radiation. NCI Thesaurus | lovastatin
A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering activity and potential antineoplastic activity. Lovastatin is hydrolyszed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in the cholesterol biosynthesis. In addition, this agent may inhibit tumor cell proliferation and reduce tumor cell invasiveness, thereby decreasing tumor metastatic potential; induce tumor cell apoptosis, possibly by inhibiting protein geranylgeranylation and; arrest cells in the G1 phase of the cell cycle, an effect that sensitizes tumor cells to the cytotoxic effects of ionizing radiation.
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news articles
Data advance knowledge in statins research Mar 31, 2006
Therapeutics Daily (subscription) (press release), Outcomes data from more recent trials involving atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin, have since expanded the patient population ...
Set a daily aspirin dose not too high, not too low Mar 29, 2006
Daily Press, Researchers at Veterans Affairs and Kaiser Permanente in California determined that splitting atorvastatin (Lipitor), lovastatin (Mevacor) and simvastatin ...
Report any muscle issues while using statin drugs Mar 27, 2006
Contra Costa Times, ...you mention. Implicated statins are lovastatin (Mevacor), simvastatin (Zocor), and possibly atorvastatin (Lipitor). The interaction ...
Anti-cholesterol foods best combined Mar 8, 2006
London Free Press, ...their diet cut LDL by more than 20 per cent -- a result equal to that achieved by a group in an earlier study taking the early-generation statin drug Lovastatin ...
Choose Foods That Keep Bad Cholesterol at Bay Mar 10, 2006
MedIndia, ...there is a drastic reduction of 20% in the LDL levels after the consumption of this combination diet when compared to those taking the statin drug, Lovastatin. ...
Chocolate can be healthful — just don't live on it Mar 19, 2006
Seattle Times, I take insulin and metformin for diabetes, atenolol and HCTZ for blood pressure, lovastatin for cholesterol and Prilosec for reflux. ...
A cholesterol-lowering drug changes patient's white hair to gray Mar 22, 2006
Daily Press, I eat carefully, but I take a lot of medicines: insulin and metformin for diabetes, atenolol and HCTZ for blood pressure, lovastatin for cholesterol and ...
Combining certain foods can lower cholesterol for some as well as ... Mar 8, 2006
Canada.com, ...diet cut LDL by more than 20 per cent - a result comparable to that achieved by a group in an earlier study taking the early-generation statin drug, Lovastatin ...
Cholesterol – What Is It and Are You At Risk? Mar 13, 2006
DailyIndia.com, HMG-CoA reductase inhibitors, ‘Statins’, such as lovastatin (Mevacor) and atorvastatin (Lipitor) are the most effective and widely used medications to ...
Crestor shown to help unclog arteries Mar 14, 2006
The News Journal, There is already at least one generic statin available, called Lovastatin, which has a 1.6 percent market share, according to IMS Health.
88% Of GPs in the UK Prefer Physical Exercise or Diet as the ... Mar 15, 2006
Genetic Engineering News, ...of the most widely prescribed drugs for constituents of the metabolic syndrome (eg, metformin, glibenclamide, simvastatin, lovastatin, pravastatin, ramipril ...
New Analysis Showed VYTORIN(R) (ezetimibe/simvastatin) Superior to ... Mar 13, 2006
Genetic Engineering News, Clin Pharmacol Ther 1998;64(5):477-83. (2) Manson, JM, Freyssinges, C., Ducrocq, MB, Stephenson, WP, Postmarketing Surveillance of Lovastatin and Simvastatin ...
About 5% of Long-term Niacin Users Evolve Into HDL Hyperresponders ... Mar 14, 2006
DG News In investigating "HDL creep" -- a phenomenon noted in studies of extended release niacin combined with a statin (niacin/lovastatin-Advicor), Leonard Keilson, MD ...
More Studies Find More Savings if Seniors Use Generic Drugs Mar 3, 2006
SeniorJournal.com, ...statins� to moderately lower their cholesterol could save up to $3.50 a day by considering the only generic version available – lovastatin, the Consumer ...
Medicare Q&A: 'Plan D' questions and answers Feb 26, 2006
Austin American-Statesman (subscription), For example, Humana charges less for other cholesterol-lowering drugs, such as the generic lovastatin or brand names Lipitor or Crestor. ...
Medical cure for learning disability Dec 5, 2005
Deccan Herald, ...research paper in Current Biology, Vol 15, November 2005) have tried a commonly prescribed cholesterol-lowering statin drug — called lovastatin, on adult ...
Lipitor Free from Generic Competition Until 2011 Dec 18, 2005
SeniorJournal.com, ...statins� to moderately lower their cholesterol could save up to $3.50 a day by considering the only generic version available – lovastatin, the Consumer ...
There are other options for men besides Viagra Dec 14, 2005
Daily Press, Women who consumed more tuna were less likely to complain of dry eyes. Q: My doctor recently put me on lovastatin because my cholesterol is 245. ...
Mix of pills merits a review Dec 12, 2005
Los Angeles Times, ...effects. Please ask his doctor to review his medications. My doctor recently put me on lovastatin because my cholesterol is 245. I ...
Picking right Medicare drug plan is a challenge Dec 7, 2005
Daily Press, Following such a diet lowered most people's cholesterol about as much as the drug lovastatin (Current Atherosclerosis Reports, November 2004). ...
Matrix to buy 55% in Concord Bio Dec 6, 2005
Business Standard, ...programmes. Concord has filed for DMFs (drug master files) for lovastatin, simvastatin and tacrolimus with the US FDA. Dossiers ...
- By Our Correspondent Dec 6, 2005
The Asian Age, ...majority representation. Concord has filed Drug Master Files for Lovastatin, Simvastatin and Tacrolimus with the US FDA. Dossiers ...
Boehringer Ingelheim Announces 48-Week Results from Aptivus(R) ... Nov 21, 2005
Yahoo! News (press release) ...threatening events. Taking APTIVUS/r with rifampin, St. John's wort, lovastatin, or simvastatin is not recommended. Caution should ...
Treatment reduces risk of heart attack by 60 to 90 percent ... Nov 30, 2005
uwnews.org, Brown was director of the first study in the late 1980s that showed that a member of the statin class, lovastatin, could cause improvement in arterial blockage ...
There's more to a plan than the price Dec 3, 2005
St. Petersburg Times, The drugs used in the test were: Albuterol aerosol, Aricept, Avandia, Cozaar, Detrol LA, Fosamax, Lipitor, Lovastatin, Nexium and Lunesta.
Some juice, drugs not a good mix Nov 27, 2005
Los Angeles Times, Grapefruit juice can raise blood levels of some cholesterol-lowering drugs, including Lipitor, Zocor and Mevacor (lovastatin), and increase the risk of side ...
FDA Approves Updated Labeling for LEXIVA Nov 18, 2005
Finanzen.net, LEXIVA. LEXIVA should not be coadministered with rifampin, St. John's wort, lovastatin, simvastatin or delavirdine. Particular caution ...
New Data Show a Kaletra(R) (Lopinavir/Ritonavir)-Based Regimen ... Nov 18, 2005
Yahoo! News (press release) In addition, Kaletra should not be taken with fluticasone propionate, lovastatin, rifampin, simvastatin, or products containing St. ...
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