interleukin-4
information and resources from the National Cancer Institute
NCI Thesaurus | interleukin-4
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-4 (IL-4). Produced primarily by activated T-cells, IL-4 binds to and activates its cell-surface receptor, stimulating the proliferation and differentiation of activated B-cells and enhancing their ability to present antigens to T-cells. As a potential immunotherapeutic agent, recombinant IL-4 also augments the effects of other cytokines on dendritic cells (DC), cytotoxic T lymphocytes (CTL), and tumor-infiltrating lymphocytes (TIL). NCI Thesaurus | interleukin-4
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-4 (IL-4). Produced primarily by activated T-cells, IL-4 binds to and activates its cell-surface receptor, stimulating the proliferation and differentiation of activated B-cells and enhancing their ability to present antigens to T-cells. As a potential immunotherapeutic agent, recombinant IL-4 also augments the effects of other cytokines on dendritic cells (DC), cytotoxic T lymphocytes (CTL), and tumor-infiltrating lymphocytes (TIL).
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news articles
American Journal of Respiratory and Critical Care Medicine Vol 173 ... Mar 28, 2006
AJRCCM (subscription), ...or T-box 21) on chromosome 17q21 regulates helper T-cell type 1 (Th1) lineage development by inducing IFN- production and by inhibiting interleukin 4 (IL-4 ...
Defective Immune System Response to Smallpox Vaccine Detailed in ... Mar 27, 2006
Kansas City infoZine, ...month's issue of "Immunity", the study details how the overproduction in skin cells of inflammation-promoting molecules called interleukin-4 and interleukin-13 ...
Smallpox Vaccination Complication Linked to Innate Immune System Mar 22, 2006
MedPage Today, But in experiments with cultured skin, neutralizing two cytokines -- interleukin-3 and interleukin-4 -- restored the innate immune response, according to ...
Research suggests therapy against serious side effects of smallpox ... Mar 21, 2006
RxPG NEWS, Atopic dermatitis patients have high levels of signaling molecules interleukin-4 (IL-4) and interleukin-13 (IL-13) in their skin. ...
Good Cell, Bad Cell Mar 23, 2006
Science Now, When the researchers looked at the response of microglia in these animals to various levels of IFN-gamma and a related protein, interleukin-4 (IL-4), they ...
CD4+ Invariant T-Cell–Receptor+ Natural Killer T Cells in ... Mar 15, 2006
New England Journal of Medicine (subscription), ...with an inflammatory process that is characterized by the presence in the airways of large numbers of CD4+ T cells producing interleukin-4 and interleukin-13. ...
A novel type of T helper cells found to be a key to inflammatory ... Nov 22, 2005
Xagena.it, Although TH1 and TH2 are known to produce powerful cytokines - such as interferon-gamma ( IFN-g ) and allergy-associated interleukin 4 ( IL-4 ), respectively ...
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