interferon alfa
information and resources from the National Cancer Institute
NCI Thesaurus | interferon alfa
A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity).NCI Thesaurus | interferon alfa
A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity).
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news articles
Gastroenterology issues probed 01 Apr 2006
Trade Arabia, ...virus. PEGASYS, (pegylated interferon alfa-2a), is the most frequently prescribed pegylated interferon for patients with hepatitis C. ...
Hepatitis C Treatment for People With Severe Mental Illness Feb 28, 2006
Psychosomatics (subscription) Fried M, Schiffman M, Reddy R, et al: Pegylated (40kDa) (PEGASYS) interferon alfa-2a in combination with ribavirin: efficacy and safety results from a phase III ...
- Interim 12-Week Data Suggest At Least Comparable Antiviral ... Mar 14, 2006
PR Newswire (press release), Interim (week 12) Phase 2b virological efficacy and safety results of albumin interferon alfa-2b combined with ribavirin in genotype 1 chronic hepatitis C ...
Idenix Provides Update on Clinical Development of Valopicitabine ... Mar 23, 2006
PR Newswire (press release), ...randomized treatment arms, all involving dosing regimens of valopicitabine, administered once-daily, in combination with pegylated interferon alfa-2a (Pegasys(R ...
Antibodies Neutralizing Peginterferon Alfa during Retreatment of ... Mar 22, 2006
New England Journal of Medicine (subscription), ...a virologic response to peginterferon and had a virtual absence of circulating peginterferon alfa-2a but had neutralizing antibodies against interferon alfa. ...
Idenix Announces Thirteen Data Presentations at the 2006 European ... Mar 17, 2006
PR Newswire (press release), Dr. Xiao-Jian Zhou, Idenix's Associate Director, Clinical Pharmacology, will present "Absence of Effect of Pegylated Interferon Alfa-2b on the Pharmacokinetics ...
Idenix Provides Update on Clinical Development of Valopicitabine ... Mar 23, 2006
PR Newswire (press release), ...patients was designed to evaluate three dosing regimens of valopicitabine, administered once-daily, in combination with pegylated interferon alfa-2a (Pegasys(R ...
Healthcare: At a Glance - Roche Hepatitis Drug Thrust Onto Front ... Mar 3, 2006
International News Service, GlaxoSmithKline's Epivir (lamivudine) is the best-known product in this disease area, although Schering-Plough's Intron A (interferon alfa-2b) is also used to ...
SP rises on deal and analyst upgrades Mar 21, 2006
Pharma Times (subscription), ...since the demise of Rebetol (ribavirin) to generic competition and with increasing rivalry seen for its newer offering Peg-Intron (peg-interferon alfa 2b). ...
HCV Data Drop HGS’ Shares; ‘Not Slam-Dunk,’ Analyst Says Mar 14, 2006
BioWorld Online (subscription), ...interferon alpha 2b), given every other week, at 12 weeks worked as well as the standard of care, which is weekly Pegasys (pegylated interferon alfa-2a) from F ...
Clinical Trials Update: Dec. 20, 2005 Dec 20, 2005
Forbes The purpose of this study is to see how safe it is to take NM283 and pegylated interferon alfa together and to measure how well this drug combination works to ...
No Benefit for Stage II Melanoma with Addition of Isotretinoin Nov 29, 2005
Cancer Consultants (press release), According to a recent article published in the Journal of Clinical Oncology, the addition of isotretinoin to interferon alfa provides no benefit over ...
Partial 24-Week Data Demonstrate Valopicitabine (NM283) Combined ... Dec 14, 2005
PR Newswire (press release), In all three arms, valopicitabine is given in combination with pegylated interferon alfa-2a (Pegasys(R)) 180 5g with the initial dose of pegylated interferon ...
TODAY ON PHARMALIVE.COM Dec 14, 2005
PharmaLive.com (press release), In all three arms, valopicitabine is given in combination with pegylated interferon alfa-2a (Pegasys(R)) 180 µg with the initial dose of pegylated ...
Viramidine May Reduce Anemia Complications of Hepatitis C ... Dec 16, 2005
DG News ...[Presentation title: Hemoglobin Decline and Anemia During HCV Therapy with Pegylated Interferon Alfa-2a with Either Viramidine or Ribavirin. Abstract 108].
Livers Under Wrap: ASLD 2005 Nov 25, 2005
MedPage Today, Treatment with pegylated interferon alfa-2a alone or in combination with Rebetol (Copegus) produces durable SVR in patients treated for hepatitis C infection ...
Imatinib Therapy Shows Positive Results After 4 Years in Chronic ... Dec 14, 2005
DG News Randomized Interferon vs. STI 571 (IRIS) study that compared imatinib therapy with interferon-alfa plus cytarabine. The IRIS study ...
Three Rivers Pharmaceuticals Announces FDA Final Approval of ... Dec 5, 2005
PR Newswire (press release), FDA) has granted final approval for its Ribasphere(R) (ribavirin, USP) Tablets 600 mg, 400 mg, and 200 mg in combination with interferon alfa-2a for the ...
GeneMedix value finally unlocked Dec 6, 2005
Business Weekly, The company also has interferon-alfa, GM-CSF and a monomeric, rapid acting, insulin in its portfolio. The process development programme ...
New Studies Identify Advances In Treatment Of Chronic Myeloid ... Dec 13, 2005
Science Daily (press release) Interferon vs. STI 571 (IRIS) study that prospectively compared imatinib therapy with interferon-alfa plus cytarabine. The IRIS ...
Bird flu: a new dread - III Dec 2, 2005
GreaterKashmir.com (press release), ...investigational interest for treatment include zanamivir, peramivir, long-acting topical neuraminidase inhibitors, ribavirin, and possibly, interferon alfa. ...
Par, Three Rivers Get FDA OK on Ribasphere Dec 5, 2005
Schaeffers Research, The agency approved Ribasphere in 200 milligram, 400 milligram and 600 milligram tablets for use with interferon alfa-2a to treat hepatitis C. ...
Rituxan® Plus CHOP Improves Outcomes of Patients with Follicular ... Nov 22, 2005
Cancer Consultants (press release), A secondary randomization in patients under the age of 60 years were allocated patients to stem cell transplantation or interferon alfa (INF-A) maintenance ...
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