indomethacin
information and resources from the National Cancer Institute
NCI Thesaurus | indomethacin
A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. NCI Thesaurus | indomethacin
A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis.
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news articles
Anti-Inflammatories Ward Off Parkinson’s -Study Mar 31, 2006
PakTribune.com, These drugs include ibuprofen, indomethacin and naproxen -- which can carry their own risks from long-term use such as liver damage. ...
Cervical Varix as a Cause of Vaginal Bleeding During Pregnancy Mar 27, 2006
Journal of Ultrasound in Medicine U of red blood cells. Indomethacin was also administered for 48 hours because of uterine contractions. A complete course of corticosteroids ...
Dutton Associates Announces Investment Opinion: AlphaRx ... Mar 20, 2006
Business Wire (press release), ...number one product development priority is to fully commercialize a topical version of the nonsteroidal anti-inflammatory drug (NSAID) indomethacin in the ...
Killing Vaccine Pains Mar 14, 2006
Newindpress (subscription), Brufen, Ibugesic, Combiflam), Nimesulide ( Nise, Nimulide, Sumo), Diclofenac (Voveran, Diclowin), Naproxen (Artagen, Naprosyn), Indomethacin (Indocap, Microcid ...
Diazepam Attenuates Phenylephrine-Induced Contractions in Rat ... Mar 9, 2006
Anesthesia & Analgesia (subscription), ...from the endothelium-intact rings pretreated independently with NW -nitro-l-arginine methyl ester, PK 11195, tetraethylammonium, and indomethacin in the ...
AlphaRx's Joint Venture Company Receives Marketing Approval for ... Mar 8, 2006
PrimeZone (press release), Flexogan Ultra contains 1% Indomethacin which is used to relieve the pain, tenderness, inflammation (swelling), and stiffness caused by gout, arthritis, and ...
KEN RUCKER SUSPENDED Dec 10, 2005
Harnesslink, ...rainer Ken Rucker has received six suspensions of 30 days each for positive tests for indomethacin in his home state of Illinois according to harnessracing ...
The importance of maturational studies in airway smooth muscle Nov 30, 2005
AJP-Lung Physiology They then showed that indomethacin, known to inhibit the intracellular cyclooxygenase pathway, eliminated the oscillation-induced force potentiation in newborn ...
Adding a Research Component to Clinical Practice Nov 30, 2005
Medscape (subscription) ...[2-5] Another round of research around 2002 related to the effect of age and birth weight on indomethacin pharmacodynamics in neonates treated for patent ...
Government backs down on PBS cuts Nov 29, 2005
AustralianDoctor.com (subscription), The addition of diazepam, diclofenac, ibuprofen, indomethacin, naproxen, nitrazepam, oxazepam, sulindac and temazepam to the palliative care section of the ...
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