genistein
information and resources from the National Cancer Institute
genistein
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. genistein
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities.
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news articles
Type of food affects soy isoflavone bioavailability Mar 30, 2006
NutraIngredients.com, 17, pp. 257-264) investigated the availability of the isoflavones daidzein and genistein from cookies, chocolate bars and juice. ...
Soy before birth could reduce offspring obesity risk, say ... Mar 29, 2006
FoodNavigator-USA, Scientists at Duke University Medical Center have revealed that mice fed diets rich in the soy component genistein gave birth to pups that remained slimmer as ...
Independent panel to evaluate Genistein or soy formula human ... Mar 8, 2006
EurekAlert (press release), ...of the NIEHS and National Toxicology Program, will review recent scientific data and reach conclusions regarding whether or not exposure to genistein or soy ...
Study: Soy nutrient reduces obesity risk Mar 28, 2006
Monsters and Critics.com, In the Duke study, pregnant Agouti mice that ate a diet rich in genistein -- an active ingredient in soy -- gave birth to pups that stayed slimmer as adults. ...
Prenatal soy fights obesity Mar 28, 2006
Health24.com, A soy ingredient called genistein causes genetic changes that permanently reduce an embryo's risk of obesity after birth, according to an animal study by ...
Studies Can't Prove Soy Formula Risks Mar 17, 2006
FOX News Experts say they have little concern that an estrogen-like substance in soy -- known as genistein -- poses a developmental risk to infants who consume it or ...
Soy Component Associated with Abnormal Ovary and Egg Development ... Mar 9, 2006
Newswise (press release) The study, “Neonatal Genistein Treatment Alters Ovarian Differentiation in the Mouse: Inhibition of Oocyte Nest Breakdown and Increased Oocyte Survival ...
Soy products pose no threat for infants, experts say Mar 20, 2006
NutraIngredients.com, The main concerns have been aimed at genistein, a naturally occurring plant oestrogen or phytoestrogen in soybeans that can mimic the effects of oestrogen in ...
Concern over soy's effect on babies 'negligible' Mar 19, 2006
USA Today Genistein is a plant estrogen, but it is 10,000 to 20,000 times less potent than estradiol, the most common estrogen produced in the human body, said panel ...
Studies Short on Soy Formula Risks Mar 17, 2006
WebMD Experts say they have little concern that an estrogen-like substance in soy -- known as genistein -- poses a developmental risk to infants who consume it or ...
Scientists to evaluate reproductive dangers of soy Mar 13, 2006
FoodNavigator-USA, By Lorraine Heller. 3/13/2006 - An independent panel of scientists is to meet this week to review recent scientific data on the soy compound genistein. ...
Duke in the News: March 28, 2006 Mar 28, 2006
Duke University, News, March 27 -- A soy ingredient called genistein causes genetic changes that permanently reduce an embryo's risk of obesity after birth, according to an ...
Statement Of Facts Concerning Soy Infant Formula Mar 20, 2006
Medical News Today (press release), ...(3). Genistein, an amino acid, is naturally present in soybeans. Some researchers have injected genistein into rodents and applied their findings to humans. ...
NIH panel to review soy safety Mar 14, 2006
USA Today ...products. Edamame, or fresh soybean pods, contain genistein, a plant estrogen found in soy products. By H. Darr Beiser, USA TODAY. ...
CO2, Temperature and Soil Nitrogen Effects on Soybean Seed ... Mar 21, 2006
CO2 Science Magazine, These isoflavones included three aglycons (daidzein, genistein, glycitein), three glucosides (diadzin, genistin, glycitin), three acetyl conjugates (6"-O ...
Soy Baby Formula's Long-Term Impact to Get Review (Update1) Mar 8, 2006
Bloomberg A panel of 14 experts will be asked to draw conclusions or suggest more research on the impact of a soy formula ingredient called genistein on human growth ...
DSM raises vitamin and carotenoid prices Mar 17, 2006
NutraIngredients.com, ...products, which now make up 20 per cent of its portfolio. These include TeaVigo green tea extract and Bonistein high-purity genistein.
Manhattan Nuclear Nightmare Mar 19, 2006
Archinect A soybean isoflavone called genistein also appears to provide modest levels of radioprotection, with virtually no side effects. ...
Soy formula, product review eyes safety Mar 15, 2006
United Press International WASHINGTON, March 15 (UPI) -- An independent US panel will examine the safety of soybean-based baby formula and the plant estrogen genistein in soy products, a ...
Soy-isoflavone-enriched foods and markers of lipid and glucose ... Mar 7, 2006
Am J Clin Nutr (subscription), Isoflavone-enriched (genistein-to-daidzein ratio of 2:1; 50 mg/d) or placebo cereal bars were consumed for 8 wk, with a wash-out period of 8 wk before the ...
Smoking and Obesity More Prevalent Among Psoriasis Patients Dec 20, 2005
Kansas City infoZine, ...members of Mount Sinai's Department of Dermatology hold patents for short-contact tazarotene therapy, excimer laser treatment of vitiligo, and topical genistein ...
Soy Isoflavones Lower Postmenopausal CVD Risk Dec 14, 2005
Natural Products Industry Insider, For eight weeks, the women consumed cereal bars enriched with 50 mg soy isoflavones, with a genistein-to-daidzein ratio of 2-to-1, or placebo cereal bars, with ...
Soy May Cause Infertility Dec 8, 2005
ShortNews.com, It has been found that the plant chemical genistein, found in soy, tofu, and legumes, can potentially damage sperm by mimicking the female hormone estrogen. ...
Nutrition Notes: Soy Is Still a Puzzle Dec 5, 2005
Kansas City infoZine, Although soy foods are often suggested for their phytochemicals like genistein, the impact of traditional soy foods such as tofu, soy nuts and soymilk are ...
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