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geldanamycin analogue
geldanamycin analogue
information and resources from the National Cancer Institute
NCI Thesaurus | geldanamycin analogue
A class of agents containing analogues of the benzoquinone antineoplastic antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. NCI Thesaurus | geldanamycin analogue
A class of agents containing analogues of the benzoquinone antineoplastic antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
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geldanamycin analogue
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