forodesine hydrochloride
information and resources from the National Cancer Institute
NCI Thesaurus | forodesine hydrochloride
The hydrochloride salt of the synthetic high-affinity transition-state analogue forodesine. Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction. NCI Thesaurus | forodesine hydrochloride
The hydrochloride salt of the synthetic high-affinity transition-state analogue forodesine. Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction.
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news articles
BioCryst Announces Presentation of Fodosine(TM) Data During the ... Dec 12, 2005
Yahoo! News (press release) ...informational update summarizing highlights from three presentations related to the clinical development of Fodosine(TM) (forodesine hydrochloride), its lead ...
BioCryst Announces Publication of Abstracts on Fodosine(TM) and ... Nov 17, 2005
PR Newswire (press release), ...(NASDAQ: BCRX) today announced that three abstracts related to the clinical development of Fodosine(TM) (forodesine hydrochloride), its lead product candidate ...
Biogen Idec Finds That Nogo Receptor Could Play a Role in the ... Nov 18, 2005
Financial News USA (press release), ...(Nasdaq: BCRX) recently announced that three abstracts related to the clinical development of Fodosine(TM) (forodesine hydrochloride), its lead product ...
BioCryst Announces Presentation of Fodosine(TM) Data During the ... Dec 12, 2005
Yahoo! News (press release) ...informational update summarizing highlights from three presentations related to the clinical development of Fodosine(TM) (forodesine hydrochloride), its lead ...
BioCryst Announces Publication of Abstracts on Fodosine(TM) and ... Nov 17, 2005
PR Newswire (press release), ...(NASDAQ: BCRX) today announced that three abstracts related to the clinical development of Fodosine(TM) (forodesine hydrochloride), its lead product candidate ...
Biogen Idec Finds That Nogo Receptor Could Play a Role in the ... Nov 18, 2005
Financial News USA (press release), ...(Nasdaq: BCRX) recently announced that three abstracts related to the clinical development of Fodosine(TM) (forodesine hydrochloride), its lead product ...
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