|
fluorouracil-uracil
fluorouracil-uracil
information and resources from the National Cancer Institute
NCI Thesaurus | fluorouracil-uracil
A formulated therapeutic oral agent consisting of a combination of 5-fluorouracil (5-FU) and uracil (1:4). Because of its higher concentration in the combination, uracil saturates the uracil-reducing enzymatic activity of dihydropyrimidine dehydrogenase, thereby inhibiting first-pass dihydropyrimidine dehydrogenase-mediated hepatic metabolism of the uracil analogue 5-FU and permitting oral administration of 5-FU. 5-FU inhibits the enzyme thymidylate synthase, resulting in decreased thymidine synthesis and so reduced DNA synthesis and tumor cell cytotoxicity. NCI Thesaurus | fluorouracil-uracil
A formulated therapeutic oral agent consisting of a combination of 5-fluorouracil (5-FU) and uracil (1:4). Because of its higher concentration in the combination, uracil saturates the uracil-reducing enzymatic activity of dihydropyrimidine dehydrogenase, thereby inhibiting first-pass dihydropyrimidine dehydrogenase-mediated hepatic metabolism of the uracil analogue 5-FU and permitting oral administration of 5-FU. 5-FU inhibits the enzyme thymidylate synthase, resulting in decreased thymidine synthesis and so reduced DNA synthesis and tumor cell cytotoxicity.
|
|
|
|
|
|
fluorouracil-uracil
-->
|
