etoposide
information and resources from the National Cancer Institute
etoposide
A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. etoposide
A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
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news articles
ICE Plus CAV Intensification Promising for High Risk Ewing’s ... Mar 31, 2006
Cancer Consultants (press release), Researchers from Italy have reported that an induction regimen of ifosfamide, carboplatin and etoposide (ICE) followed by intensification with cyclophosphamide ...
Gemzar®/Platinol® Superior to VePesid®/Platinol® in Non-Small ... Mar 29, 2006
Cancer Consultants (press release), ...the chemotherapy combination consisting of Gemzar® (gemcitabine) plus Platinol® (cisplatin) improves outcomes compared to VePesid® (etoposide) plus Platinol ...
Sunesis Pharmaceuticals Initiates Phase II Clinical Trial of SNS ... Mar 20, 2006
Yahoo! News (press release) ...line treatment for small cell lung cancer typically involves use of a platinum drug such as cisplatin in combination with a second agent, typically etoposide. ...
Concurrent Radiation Therapy and Chemotherapy for Small Cell Lung ... Mar 16, 2006
Cancer Consultants (press release), ...published in the British Journal of Cancer, chemotherapy including Paraplatin® (carboplatin), Taxol® (paclitaxel), and Vepesid® (etoposide) plus radiation ...
Chemotherapy for Immune Disorder Suggested as Avian Flu Treatment Mar 3, 2006
CNN In 1994, a treatment protocol for HLH was developed, based on corticosteroids, etoposide, cyclosporine A, and intrathecal methotrexate. ...
New Avian flu Treatment Mar 2, 2006
Ivanhoe, The chemotherapy drug etoposide is used to treat HLH. It helps kill the excess immune cells. Professor Jan-Inge Henter, MD, Ph.D ...
Swedish theory suggests treatment for Avian Influenza Infection Mar 8, 2006
News-Medical.net, ...of organs. One of the key treatments for HLH is the chemotherapy drug etoposide, which helps kill the excess of immune cells. The ...
Sunesis initiates phase II lung cancer trial Mar 21, 2006
Pharmaceutical Business Review ...a meaningful benefit in second-line treatment as we have observed evidence of SNS-595's activity in platinum-resistant and etoposide-resistant xenograft models ...
Chemotherapy may help bird flu victims Mar 2, 2006
NewKerala.com, ...both in its inherited form and in response to the Epstein-Barr virus, can be treated with drugs, including a key chemotherapy called etoposide, which kills ...
Concurrent Radiation Therapy and Chemotherapy for Small Cell Lung ... Mar 16, 2006
Cancer Consultants (press release), ...small cell lung cancer (SCLC) following concurrent radiotherapy and chemotherapy with Paraplatin® (carboplatin), Taxol® (paclitaxel) and Vepesid® (etoposide ...
Select AIDS, cancer drugs to become cheaper Mar 2, 2006
Sify, ...of the cancer drugs expected to see a downward price revision are cisplatin, cytosine arabinoside, danazol, daunorubicin HCL, etoposide, flutamide, ondansetron ...
Patients with Unfavorable Risk Hodgkin’s Lymphoma May Not ... 21 Dec 2005
Cancer Consultants (press release), BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) is a more intensive regimen that has also been ...
Patients With Unfavorable Risk Hodgkin’s Lymphoma May Not ... Dec 19, 2005
Cancer Consultants (press release), BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) is a more intensive regimen which has also been evaluated ...
Adding Radioimmunotherapy To Chemotherapy Reduces Relapse Risk In ... Dec 17, 2005
Medical News Today (press release), ...blood stem cells were collected, after which they received a high dose of Zevalin followed by the chemotherapeutic drug cyclophosphamide and etoposide. ...
ATLANTA -- Abstracts Presented at 2005 ASH Annual Meeting Reveal ... Dec 14, 2005
dBusinessNews Atlanta (press release), The first was a phase I/II dose escalation trial of high-dose ZEVALIN plus cyclophosphamide and etoposide. The second study was ...
JCI table of contents: December 15, 2005 Dec 15, 2005
EurekAlert (press release), While etoposide, a Topo II inhibitor, has been used for over 20 years in the treatment of a variety of malignancies, an unfortunate complication of this ...
National Study Improves Outcome For Pediatric Acute Myeloid ... Dec 14, 2005
Science Daily (press release) ...multi-center AML02 trial randomly assigns patients to receive either high- or low-dose treatment with cytarabine (A), daunorubicin (D), and etoposide (E) as ...
ASH: Oral Targeted Agent Boosts Remissions in Poor-Prognosis AML Dec 14, 2005
MedPage Today, Patients whose remissions lasted one to six months received the MEC regimen (consisting of mitoxantrone, etoposide, and cytarabine), while those whose ...
New Data Demonstrate ZEVALIN(R) Radioimmunotherapy May Play ... Dec 13, 2005
Finanzen.net, The first was a phase I/II dose escalation trial ofhigh-dose ZEVALIN plus cyclophosphamide and etoposide. The secondstudy was a ...
Combination chemotherapies slow small cell lung cancer and cancer ... Nov 30, 2005
PharmaLive.com (press release), The combination of paclitaxel/carboplatin/etoposide as a first line treatment produces significant improvement in stopping progression of extensive stage small ...
Age Makes Little Difference in Outcomes for Non-Hodgkin's Lymphoma ... Dec 12, 2005
DG News ...who relapsed and underwent autologous stem cell transplant following BEAM conditioning, which combines BCNU (carmustine), etoposide, cytosine arabinoside, and ...
Tandem High-Dose Chemotherapy Superior to Dose-Dense Chemotherapy ... Dec 5, 2005
Cancer Consultants (press release), Following 2 cycles of EP, patients in the tandem transplant arm received 2 cycles of high-dose etoposide, cyclophosphamide and thiotepa with stem cell support. ...
Intensive Chemotherapy Regimen Shows Promise for Germ Cell Tumors Dec 5, 2005
Cancer Consultants (press release), ...of cisplatin, vincristine, bleomycin, and carboplatin, followed by one cycle of vincristin and bleomycin and three cycles of bleomycon, etoposide, and cisplatin ...
Long-term remission after autologous peripheral blood stem cell ... Nov 24, 2005
Nature.com (subscription), ...but she achieved a second CR after five courses of dose-modified CHASE therapy (cytarabine 130 mg/m 2 3 days, cyclophosphamide 800 mg/m 2 1 day, etoposide 70 mg ...
Induction Chemotherapy and Concomitant Chemoradiotherapy Promising ... Dec 6, 2005
Cancer Consultants (press release), ...gemcitabine and vinorelbine. This was followed by oral etoposide and cisplatin given concurrently with radiation therapy. 29 patients ...
Accentia Biopharmaceuticals announces that follow-up data Dec 2, 2005
EurekAlert (press release), ...non-Hodgkin's lymphoma are being treated with BiovaxID immunotherapy following PACE [Prednisone, Doxorubicin, Cyclophosphamide, and Etoposide (ProMACE without ...
Cancer treatment improved by tweaking genes Nov 23, 2005
The California Aggie Online ...switch process. Other anti-cancer agents, such as etoposide, cisplatin and vinblastine were not affected by Ku86 manipulation. The ...
Genetic switch involved in cells' response to radiation therapy ... Nov 20, 2005
Medical News Today (press release), Ku86 had no effect on the radiosensitizing abilities of other anti-cancer agents tested - etoposide, cisplatin and vinblastine. ...
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