etanercept
information and resources from the National Cancer Institute
NCI Thesaurus | etanercept
A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. NCI Thesaurus | etanercept
A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation.
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news articles
Use of the Existing Cytokine Therapeutics in Inflammatory ... Mar 31, 2006
Genetic Engineering News, ...disease (CD). Nearly all sales were generated by the three available anti-TNF-a agents: etanercept, infliximab, and adalimumab. Twenty ...
Tumor Necrosis Factor- Mediates Diabetes-Enhanced Apoptosis of ... Feb 28, 2006
Am J Pathology (subscription) ...we inoculated Porphyromonas gingivalis into the scalp of type 2 diabetic (db/db) or control mice and inhibited tumor necrosis factor (TNF- ) with etanercept. ...
FDA Approves Rituxan for Refractory Rheumatoid Arthritis Mar 1, 2006
MedPage Today, ...for use in combination with methotrexate in patients with moderate-to-severe RA that has been refractory to treatment with Enbrel (etanercept) or Remicade ...
Genentech/Biogen Idec: Rituxan further expands its options Mar 2, 2006
Pharmaceutical Business Review ...one or two traditional disease-modifying treatments (DMARDs), followed by the more expensive biologics such as Amgen's Enbrel (etanercept) or Johnson & ...
Old News! Feb 28, 2006
Joplin Independent, My wife is on a Rheumatoid Arthritis medication which is a TNF receptor blocker called etanercept, trade name ENBREL, made by AMGEN, a division of Wyeth. ...
FDA clears Rituxan for rheumatoid arthritis Mar 1, 2006
Pharma Times (subscription), ...responded to biologic therapy based on tumour necrosis factor blockers, namely Centocor's Remicade (infliximab), Amgen/Wyeth's Enbrel (etanercept) and Abbott ...
Genentech, Biogen Idec Gain Approval Of Rituxan In RA Mar 1, 2006
BioWorld Online (subscription), ...an inadequate response or were intolerant to prior treatment with methotrexate and one or more TNF antagonist therapies such as Enbrel (etanercept, from Amgen ...
BAMBOO SPINE, A SPECIAL KIND OF ARTHRITIS Feb 25, 2006
Charlotte Sun-Herald, Pamidronate, a medicine used for osteoporosis, has also been found effective for AS; so have two newer drugs, infliximab and etanercept. DEAR DR. ...
Psoriasis drug may treat depression, fatigue 21 Dec 2005
myDNA.com, A new study shows that the psoriasis drug called Enbrel (etanercept), made by the California-based Amgen company, appears to also reduce depression and fatigue ...
New Drugs Offer More Choices for Psoriasis 21 Dec 2005
Spartanburg Herald Journal (subscription), Since 2003, biologic drugs approved for psoriatic arthritis or psoriasis include Remicade; alefacept, sold as Amevive; etanercept, sold as Enbrel; efalizumab ...
Juvenile Arthritis - A Niche In The Market 21 Dec 2005
Pharmaceutical Business Review ...tax credit and marketing incentives, and all three biologic TNF-inhibitors currently have orphan designation in the US but only Enbrel (etanercept) is approved ...
Etanercept Plus Methotrexate Effective Therapy for Juvenile ... Nov 22, 2005
DG News SAN DIEGO, CA -- November 22, 2005 -- Etanercept as monotherapy or in combination with methotrexate resulted into significant improvements in the signs and ...
Switching from Methotrexate to Etanercept (Enbrel) Appears ... Nov 22, 2005
DG News ...to methotrexate monotherapy achieved significant improvements in physical function and quality of life when switched to combination etanercept (Enbrel) plus ...
Psoriasis drug hope for depression Dec 14, 2005
DeHavilland, A team of scientists in the US examined the effects of etanercept, an effective treatment for the clinical symptoms of psoriasis, on fatigue and symptoms of ...
Psoriasis Drug May Also Relieve Depression And Fatigue Linked To ... Dec 16, 2005
Medical News Today (press release), Ranga Krishnan (Duke University Medical Center, Durham, North Carolina, USA) and colleagues looked at the effect of etanercept, an effective treatment for the ...
Easing psoriasis blues Dec 16, 2005
Health24.com, Etanercept, which goes under the brand name Enbrel, works by blocking a protein called tumour necrosis factor-alpha (TNF-alpha), which is produced by the body ...
Psoriasis Drug May Also Fight Depression Dec 14, 2005
HealthCentral.com Etanercept, which goes under the brand name Enbrel, works by blocking a protein called tumor necrosis factor-alpha (TNF-alpha), which is produced by the body ...
Psoriasis Drug May Also Clear Up Depression and Fatigue Dec 15, 2005
CNN 15 - At the same time that Enbrel (etanercept), a tumor necrosis factor-alpha (TNF-a) inhibitor, relieves the clinical symptoms of psoriasis, it may also clear ...
Psoriasis drug may also cut depression: study Dec 14, 2005
Reuters A 618-patient trial of Enbrel, known generically as etanercept, found that those given the drug for 12 weeks had a 50 percent improvement in a commonly used ...
New Year, new drug for arthritis patients Dec 4, 2005
Scoop.co.nz (press release), PHARMAC already subsidises one TNF alpha inhibitor, etanercept, for juvenile rheumatoid arthritis. Etanercept will continue to be available to those patients.
Enbrel and Humira Will Dominate the Tumor Necrosis Factor-Alpha ... Nov 28, 2005
PR Newswire (press release), ...number of immune diseases being treated with tumor necrosis factor-alpha (TNF-alpha) inhibitors will enable Amgen/Wyeth/Takeda's Enbrel (etanercept) and Abbott ...
The Doctor's Choice Awards Dec 9, 2005
Medgadget.com, ...alfuzosin) in urologicals. Wyeth/Amgen's Enbrel (etanercept) took top place in anti-arthritics and dermatologicals. On the agency ...
Treatment has demonstrated improvement in physical function and ... Nov 20, 2005
Medical News Today (press release), ...agent in patients with rheumatoid arthritis (RA) demonstrated that more than three quarters of patients treated with Enbrel® (etanercept) plus methotrexate ...
Anti-TNF Drugs Cut Mortality Rates among Rheumatoid Arthritis ... Nov 18, 2005
DG News Suppression of TNF proteins with infliximab (Remicade), etanercept (Enbrel) and adalimumab (Humira), and ensuing reductions of joint inflammation has made ...
Idiopathic Pulmonary Fibrosis Has a Five-Year Survival Rate of 20% ... Nov 25, 2005
Genetic Engineering News, However, several promising anti-fibrotic agents, such as Enbrel (etanercept), are now in clinical trials, which may lead to significant improvements in disease ...
Combination Therapy With ENBREL And Methotrexate Found Effective ... Nov 21, 2005
MedIndia, Combination therapy with anti-TNF agents (etanercept) and chemotherapy drug methotrexate has been shown to be effective in the treatment of Rheumatoid Arthritis ...
ACR: CNTO-148 Demonstrates Efficacy for RA Nov 18, 2005
MedPage Today, ..."Remicade may still have a role, for example in forms of inflammatory bowel disease where Enbrel [(etanercept), another anti-TNF biologic which binds TNF alpha ...
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