doxorubicin HCl liposome
information and resources from the National Cancer Institute
NCI Thesaurus | doxorubicin HCl liposome
A liposome-encapsulated form of the hydrochloride salt of the anthracycline antineoplastic antibiotic doxorubicin. Liposomal delivery of doxorubicin HCL improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects. Doxorubicin intercalates into DNA and interacts with topoisomerase II, consequently inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. NCI Thesaurus | doxorubicin HCl liposome
A liposome-encapsulated form of the hydrochloride salt of the anthracycline antineoplastic antibiotic doxorubicin. Liposomal delivery of doxorubicin HCL improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects. Doxorubicin intercalates into DNA and interacts with topoisomerase II, consequently inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
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news articles
New Combo Treatment for Ovarian Cancer Nov 3, 2005
Ivanhoe, ...ovarian cancer, compared to a more typical response rate of between 12 percent and 15 percent, as seen with the drug DOXIL (doxorubicin HCl liposome injection ...
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