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dimesna
dimesna
information and resources from the National Cancer Institute
dimesna
A synthetic derivative of dithio-ethane sulfonate used as an uroprotective agent in chemotherapy. In vivo, dimesna undergoes reduction to mesna during intestinal absorption. Mesna exerts efficient protection against oxazaphosphorine-induced urothelial toxicity by binding to and detoxifying the urotoxic metabolites acrolein and 4-hydroxy ifosfamide. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis.dimesna
A synthetic derivative of dithio-ethane sulfonate used as an uroprotective agent in chemotherapy. In vivo, dimesna undergoes reduction to mesna during intestinal absorption. Mesna exerts efficient protection against oxazaphosphorine-induced urothelial toxicity by binding to and detoxifying the urotoxic metabolites acrolein and 4-hydroxy ifosfamide. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis.
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dimesna
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