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denileukin diftitox
denileukin diftitox
information and resources from the National Cancer Institute
NCI Thesaurus | denileukin diftitox
A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death. NCI Thesaurus | denileukin diftitox
A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death.
Ontak
Accel. Approv. (clinical benefit not established) treatment of patients with persistent or recurrent cutaneous T-cell lymphoma whose malignant cells express the CD25 component of the IL-2 receptor
Seragen, Inc Feb 05 1999
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FDA MedWatch - Ontak (denileukin Diftitox) Associated with Loss OF ... Mar 16, 2006
PharmaLive.com (press release), ROCKVILLE, Md., March 15, 2006-Ligand Pharmaceuticals and FDA notified healthcare professionals of changes to the WARNINGS section of the prescribing ...
Sanofi Will Be Losing Sleep over Potential Wave of Ambien Claims Mar 16, 2006
Newsinferno.com, ...caused chronic cases of the very same condition the drugs were designed to treat; and (3) loss of color vision caused by ONTAK (denileukin diftitox), a drug ...
denileukin diftitox
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