dactinomycin
information and resources from the National Cancer Institute
NCI Thesaurus | dactinomycin
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. NCI Thesaurus | dactinomycin
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II.
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news articles
Pediatric Studies Of Clolar, Neulasta, Kepivance To Be Discussed ... Oct 20, 2005
FDA Advisory Committee The subcommittee will also discuss the status of studies for off-patent drugs for pediatric oncology indications, with an update on vincristine and dactinomycin ...
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