cytarabine
information and resources from the National Cancer Institute
NCI Thesaurus | cytarabine
An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytosine arabinoside is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. NCI Thesaurus | cytarabine
An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytosine arabinoside is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair.
Cytosar-U Pharmacia & Upjohn Company Jun 17 1969
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news articles
For the First Time a Molecular Test Proves to be Effective in ... Mar 28, 2006
Hutchinson Center A Life of Science, ...extent of remission or the likelihood of relapse in cancer patients being treated on Gleevec or a combination therapy consisting of interferon and cytarabine. ...
Single-Agent Arsenic Trioxide Very Effective for Treatment of APL Mar 27, 2006
Cancer Consultants (press release), Consolidation in all arms was doxorubicin, cytarabine, and homoharrington administered sequentially followed by ATRA maintenance. ...
Hepatitis C Treatment for People With Severe Mental Illness Feb 28, 2006
Psychosomatics (subscription) Guilhot F, Chastang C, Michallet M, et al: Interferon alfa-2B combined with cytarabine versus interferon alone in chronic myelogenous leukemia. ...
Allos Therapeutics Reports 2005 Financial Results Mar 6, 2006
MSN Money ...study designed to compare the activity of a pralatrexate/gemcitabine combination relative to a commonly used combination of methotrexate/cytarabine (ara-C) in ...
New Drugs Improve Bone Marrow Cancer Outlook Mar 13, 2006
Wiley InterScience, New drugs, such as 5-azacytidine, lenalidomide, decitabine, and cytarabine, are now being tested for efficacy and safety to treat MDS. ...
Vion Reports 2005 Year-End and Fourth Quarter Financial Results Mar 10, 2006
Webbolt Business News (subscription), Cloretazine(R) (VNP40101M) a unique sulfonylhydrazine alkylating agent, is being evaluated in a Phase III trial in combination with cytarabine in relapsed ...
SkyePharma defeats shareholder revolt Mar 10, 2006
Pharma Times (subscription), ...drug delivery businesses, and try to find a buyer for San Diego-based injectables unit, which has two marketed products - DepoCyt (cytarabine) for lymphomatous ...
National Study Improves Outcome For Pediatric Acute Myeloid ... Dec 14, 2005
Science Daily (press release) The multi-center AML02 trial randomly assigns patients to receive either high- or low-dose treatment with cytarabine (A), daunorubicin (D), and etoposide (E ...
Lorus announces international conference presentation of the ... Dec 12, 2005
PR Newswire (press release), Hematology and Oncology and Comprehensive Cancer Center at Ohio State University, conducted the clinical trial of GTI-2040 combined with cytarabine in patients ...
ASH: Oral Targeted Agent Boosts Remissions in Poor-Prognosis AML Dec 14, 2005
MedPage Today, Patients whose remissions lasted one to six months received the MEC regimen (consisting of mitoxantrone, etoposide, and cytarabine), while those whose ...
Adding Radioimmunotherapy To Chemotherapy Reduces Relapse Risk In ... Dec 17, 2005
Medical News Today (press release), ...had their stem cells collected, but received a lower (standard) dose of Zevalin, followed by chemotherapy with BEAM (BCNU, etoposide, cytarabine and melphalan ...
Imatinib Therapy Shows Positive Results After 4 Years in Chronic ... Dec 14, 2005
DG News Randomized Interferon vs. STI 571 (IRIS) study that compared imatinib therapy with interferon-alfa plus cytarabine. The IRIS study ...
ATLANTA -- Abstracts Presented at 2005 ASH Annual Meeting Reveal ... Dec 14, 2005
dBusinessNews Atlanta (press release), ...etoposide. The second study was a phase I/II trial of standard dose ZEVALIN and BEAM (BCNU, cytarabine, etoposide, melphalan). No ...
CML Survival with Gleevec Remains High Dec 12, 2005
MedPage Today, The IRIS trial compared Gleevec with interferon plus Ara-C (Cytarabine) in more than 1,106 patients newly diagnosed with CML that is Philadelphia chromosome ...
New Studies Identify Advances In Treatment Of Chronic Myeloid ... Dec 13, 2005
Science Daily (press release) Interferon vs. STI 571 (IRIS) study that prospectively compared imatinib therapy with interferon-alfa plus cytarabine. The IRIS ...
Lorus reports positive results in drug trial Dec 13, 2005
Globe and Mail, Society of Hematology meeting in Atlanta yesterday, Toronto-based Lorus said its GTI-2040 drug combined with the chemotherapy drug cytarabine eliminated acute ...
More Than 90% of Patients Taking Gleevec(R) for a Form of Chronic ... Dec 12, 2005
Yahoo! News (press release) ...extended overall survival in newly diagnosed Ph+ CML patients in chronic phase compared with the historical treatment of interferon plus cytarabine (IFN+Ara-C ...
Vion Presents Cloretazine(R) Data at ASH Annual Meeting Dec 12, 2005
PR Newswire (press release), ...trials: Cloretazine(R), a unique sulfonylhydrazine alkylating agent, is being evaluated in a Phase III trial in combination with cytarabine in relapsed acute ...
Results of Treatment of Childhood Acute Myeloid Leukemia Reviewed Dec 7, 2005
Cancer Consultants (press release), ...treated conventionally. Their studies also suggest that adding cytarabine to induction increased 5-year EFS to 42%. Researchers ...
Surprise benefit of unexpected diagnosis Nov 23, 2005
CNN Portland, Oregon, on December 17, and after meeting with Mauro she decided to join a new clinical study testing a combination of Gleevec and Cytosar (cytarabine ...
Long-term remission after autologous peripheral blood stem cell ... Nov 24, 2005
Nature.com (subscription), Her disease was refractory to three courses of CHOP therapy, but she achieved a second CR after five courses of dose-modified CHASE therapy (cytarabine 130 mg ...
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