cyclosporine
information and resources from the National Cancer Institute
NCI Thesaurus | cyclosporine
A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. NCI Thesaurus | cyclosporine
A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release.
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news articles
Inhaled Cyclosporine improves survival for lung transplant ... Mar 3, 2006
Xagena.it, ...study, which was the first double-blind, placebo-controlled trial ever conducted in lung transplant patients, tested an inhaled form of Cyclosporine, a widely ...
New Analysis Showed VYTORIN(R) (ezetimibe/simvastatin) Superior to ... Mar 13, 2006
Genetic Engineering News, Caution should be exercised when initiating VYTORIN in patients treated with cyclosporine and in patients with severe renal insufficiency. ...
New Type of Rejection Blocker Protects Kidneys After Transplant Mar 22, 2006
eMaxHealth.com, ...a new drug that selectively blocks immune responses has proved as effective in preventing acute kidney transplant rejection as cyclosporine, the standard anti ...
Aspreva Announces Completion of Patient Enrolment in Phase III ... Mar 30, 2006
CNW Telbec (Communiqués de presse), La Roche's (Roche) leading immunosuppressant or "anti-rejection" drug used in combination with other immunosuppressive drugs (cyclosporine and corticosteroids ...
Spinal cord injury eased by stem cells Mar 29, 2006
Toronto Star, ...experiments, rats whose crushed spinal cords were injected with adult stem cells and given a cocktail of drugs — growth hormone, cyclosporine to prevent ...
Stem cells help rats with spinal cord injuries to walk Mar 29, 2006
ChronicleHerald.ca, But rats whose spinal cords were injected with adult stem cells and given a cocktail of drugs — growth hormone, cyclosporine to prevent rejection and the anti ...
Stem cells fix rat injury Mar 29, 2006
Toronto Sun, But rats whose spinal cords were injected with adult stem cells and given a cocktail of drugs -- growth hormone, cyclosporine to prevent rejection and the anti ...
Brain stem cells restore walking ability Mar 29, 2006
Food Consumer, The rats were also given drugs including growth hormone, cyclosporine to prevent rejection and the anti-inflammatory minocycline, which researchers believe ...
Inspire to Present at Southeast Invest 2006 Conference Mar 30, 2006
Genetic Engineering News, Inspire's US specialty sales force promotes Elestat(R) (epinastine HCl ophthalmic solution) 0.05% and Restasis(R) (cyclosporine ophthalmic emulsion) 0.05 ...
When arthritis strikes children Mar 27, 2006
Washington Times, ...a day. She receives an injection on Fridays of methotrexate and takes cyclosporine by mouth, also for eye inflammation. She also ...
First-Ever Large-Scale Prospective Study In Hispanic Patients With ... Mar 24, 2006
DG News ...less aggressive LDL-C reductions or who have predisposing factors for myopathy, and for special populations such as patients taking cyclosporine, Asian patients ...
Remicade(R) Approved In Australia For Treatment Of Early ... Mar 24, 2006
Medical News Today (press release), ...in adults who failed to respond to, or have a contraindication to, or are intolerant of other systemic therapy including cyclosporine, methotrexate or psoralen ...
Chemotherapy for Immune Disorder Suggested as Avian Flu Treatment Mar 3, 2006
CNN In 1994, a treatment protocol for HLH was developed, based on corticosteroids, etoposide, cyclosporine A, and intrathecal methotrexate. ...
Medicare Mailbag: Canadian drugs don't help fill 'doughnut hole' Mar 15, 2006
Palm Beach Post, December 2005. I was informed that Medicare would not cover cyclosporine, the anti-rejection medicine that I am required to take. The ...
Isotechnika Announces Preliminary 48 Week Clinical Data From the ... Mar 20, 2006
Juraforum.de, ...experiencing a clinically significant reduction in kidney function is significantly less than with other calcineurin inhibitors such as cyclosporine where the ...
PAPER TRAINED: Allergy testing may pinpoint itch Mar 18, 2006
Quad City Times, ...available. While still expensive for a dog of Emma’s size, cyclosporine has enjoyed good success in solving itchy problems. Tell ...
Idenix Announces Thirteen Data Presentations at the 2006 European ... Mar 17, 2006
PR Newswire (press release), Dr. Zhou will present "Absence of Pharmacokinetic Drug-Drug Interaction Between Telbivudine and Peginterferon alfa-2a or Cyclosporine in Healthy Subjects" in ...
Experts Expect Lung Transplant Survival Rates to Trend Upward Mar 21, 2006
Newswise (press release) Cyclosporine, which for many years was considered the cornerstone of immunosuppressant treatment, has been replaced by Prograf, a new medication. ...
Chest Service, Erasme University Hospital, Brussels, Belgium; and ... Mar 7, 2006
AJRCCM (subscription), In a study of 48 de novo recipients, Akhlaghi and colleagues showed that cyclosporine C 2 concentration correlated better with the incidence of acute rejection ...
Sawyer woman continues battle Feb 25, 2006
In-Forum (subscription), ...side effects. Now she is on another drug, cyclosporine, but it is too early to determine whether the treatment will help. Dr. James ...
Coronary Risk Scores Accurate in Liver Recipients Mar 3, 2006
MedPage Today, In contrast, neither the immunosuppressant use of cyclosporine A, tacrolimus, nor steroids were associated with cardiovascular events (P= 0.743, 0.870, and ...
Pitt renames biomedical tower for Starzl Mar 10, 2006
Bizjournals.com, In 1980, he introduced antirejection medications antilymphocyte globulin and cyclosporine, which became the accepted transplant regimen for patients with liver ...
With “Mozart Transplantation for Organ,� organ virtuoso Robert ... Mar 13, 2006
University of Pittsburgh News (press release), In 1980, he brought the field a huge step forward when he introduced the antirejection medications antilymphocyte globulin and cyclosporine. ...
Portable cocaine sensor on the cheap Feb 27, 2006
Monsters and Critics.com, Researchers also note that the sensor could be used for medical purposes in detecting and regulating prescription drug use such as cyclosporine or a family of ...
Doctors perform 1,000th heart transplant at Texas Heart Institute Feb 28, 2006
HappyNews.com, Luke's, performed the first successful heart transplant in the US at St. Luke's in 1968. "The current program began with the advent of cyclosporine (in 1982 ...
Eczema patients may soon be treated with shielding lotions Dec 20, 2005
Newstarget.com, ...antihistamines, depending on the severity, phototherapy, and for particularly severe cases, medications such as corticosteroids and cyclosporine, may be ...
Transplants' cancer threat Dec 4, 2005
Richmond Times Dispatch, Transplantation took off in the 1980s with the development of cyclosporine, an immunosuppressive drug that drastically improved patients' chances of recovery. ...
Transplant Pioneer Awarded National Medal of Science: A Newsmaker ... Dec 15, 2005
Medscape (subscription) A major advance turning the tide in transplantation research was the first use of cyclosporine by Dr. Calne in 1979, and then my demonstration that it would be ...
Face the facts Dec 11, 2005
Hindustan Times, The discovery of the powerful immunosuppressant, cyclosporine, in the Eighties made kidney, heart, pancreas, heart-lung, skin and bone marrow, and liver ...
Landmark Trials Demonstrate Benefits of Remicade (Infliximab) in ... Dec 8, 2005
DG News ...in adults who failed to respond to, or have a contraindication to, or are intolerant of other systemic therapy including cyclosporine, methotrexate or psoralen ...
Baby doing well after heart transplant Dec 11, 2005
Winona Daily News, Her eyes are watchful behind a set of thick eyelashes — a side effect of cyclosporine, one of three medications that Lilly takes to keep her body from ...
Government provides medicine to reduce infant mortality Dec 8, 2005
Dominican Today, ...official. In addition to the sulfates, other medicines such as cyclosporine, antibiotics and other first generation drugs were donated. ...
Changing organs Dec 3, 2005
Malaysia Star, Africa. In 1970, the drug cyclosporine was discovered, and transplant surgery had found it a sufficiently powerful immunosuppressive. ...
Inspire Announces Receipt of FDA Approvable Letter for Diquafosol Dec 2, 2005
Business Wire (press release), Inspire's US specialty sales force promotes Elestat(R) (epinastine HCl ophthalmic solution) 0.05% and Restasis(R) (cyclosporine ophthalmic emulsion) 0.05 ...
Inspire's Stock Tanks On Dry Eye Drug's Second Approvable Letter Dec 2, 2005
BioWorld Online (subscription), Still, Inspire had hope because the approval of Allergan Inc.'s Restasis (cyclosporine) for dry eye came after three approvable letters, Sanderson said ...
The Effect Of Tracleerâ„¢ On Male Fertility with Primary Pulmonary ... Nov 19, 2005
Community Dispatch (press release) ...the formulation. Treatment with glyburide, cyclosporine A or tacrolimus at inclusion or planned during the study. Treatment with ...
Aspreva Announces Completion of Patient Enrolment in Phase III ... Nov 28, 2005
PR Newswire (press release), La Roche's (Roche) leading immunosuppressant or "anti-rejection" drug used in combination with other immunosuppressive drugs (cyclosporine and corticosteroids ...
Results of Investigator Initiated Trial of CellCept in Lupus ... Nov 25, 2005
PR Newswire (press release), CellCept CellCept is an immunosuppressant or "anti-rejection" drug used in combination with other immunosuppressive drugs (cyclosporine and corticosteroids ...
New Data Examines Effects of Crestor Alone or in Combination with ... Nov 22, 2005
DG News ...less aggressive LDL-C reductions or who have predisposing factors for myopathy, and for special populations such as patients taking cyclosporine, Asian patients ...
IBD: Current and Future Trends Dec 1, 2005
EndoNurse, ...treatment of IBD. In addition, cyclosporine A was found to be appropriate only in severe UC after the failure of steroids. The only ...
Inspire knocked back again on dry eye drug Dec 5, 2005
Pharma Times (subscription), ...supplied the drug delivery technology underlying the product and markets the only approved product in the USA for dry eye, called Restasis (cyclosporine). ...
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