cisplatin
information and resources from the National Cancer Institute
cisplatin
An inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. cisplatin
An inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.
Platinol
as a single agent for patients with transitional cell bladder cancer which is no longer amenable to local treatments such as surgery and/or radiotherapy.
Bristol-Myers Squibb Apr 22 1993
Platinol
Metastatic ovarian tumors - in established combination therapy with other approved chemotherapeutic agents: Ovarian-in established combination therapy with other approved chemotherapeutic agents in patients with metastatic ovarian tumors who have already received appropriate surgical and/or radiotherapeutic procedures. An established combination consists of Platinol and Adriamycin. Platinol, as a single agent, is indicated as secondary therapy in patients with metastatic ovarian tumors refractory to standard chemotherapy who have not previously received Platinol therapy.
Bristol-Myers Squibb Dec 19 1978
Platinol
Metastatic testicular-in established combination therapy with other approved chemotherapeutic agents in patients with metastatic testicular tumors whoc have already received appropriate surgical and/or radiotherapeutic procedures. An established combination therapy consists of Platinol, Blenoxane and Velbam.
Bristol-Myers Squibb Dec 19 1978
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news articles
Light activated anticancer drug targeted to DNA using cisplatin ... Mar 27, 2006
News-Medical.net, One of the most effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. ...
Gemzar®/Platinol® Superior to VePesid®/Platinol® in Non-Small ... Mar 29, 2006
Cancer Consultants (press release), ...an article recently published in Lung Cancer, the chemotherapy combination consisting of Gemzar® (gemcitabine) plus Platinol® (cisplatin) improves outcomes ...
Taxotere Now Approved for Stomach Cancer Mar 31, 2006
ACS News Center, The drug may now be given along with other chemotherapy drugs (cisplatin and 5-fluorouracil) to people who have not had prior chemotherapy. ...
Chemotherapy Sequence Affects Lung Cancer Response Mar 23, 2006
Cancerpage.com, NEW YORK MAR 22, 2006 (Reuters Health) - Treatment with cisplatin followed by irinotecan appears to achieve better outcome in patients with nonsmall cell lung ...
Positive trial for Marshall Edwards anticancer drug Mar 30, 2006
Pharmaceutical Business Review The Yale researchers reported that 74% of patients with late-stage, platinum-resistant tumors who received the phenoxodiol and cisplatin combination showed ...
Sanofi-Aventis: Taxotere fighting to maintain blockbuster status Mar 29, 2006
Pharmaceutical Business Review Taxotere (docetaxel), was approved by the US regulator in combination with cisplatin and 5-flurouracil (5-FU) as a first-line treatment for metastatic gastric ...
Yale Researchers Find Phenoxodiol Restores Sensitivity to ... Mar 29, 2006
DG News ...was developed to overcome this chemical resistance within tumor cells, thereby allowing standard anti-cancer drugs such as cisplatin, carboplatin and ...
DEBIOPHARM SA INVESTS IN NANOCARRIER MEZZANINE FUNDING ROUND Mar 31, 2006
Small Times Additionally, NanoCarrier's Nanoplatin(TM) (NC-6004), a cisplatin-based new platinum compound, also utilising its MediCelle(TM) technology started Phase I ...
FDA Approvals: Aranesp, Taxotere, Leukine Mar 28, 2006
Medscape (subscription) ...alfa injection in the treatment of chemotherapy-induced anemia; a new indication for docetaxel injection, allowing its use in combination with cisplatin and 5 ...
TAXOTERE(R) Receives US FDA Approval For Use In Advanced Stomach ... Mar 23, 2006
Yahoo! News (press release) ...drug application (sNDA), the US Food and Drug Administration (FDA) has approved TAXOTERE® (docetaxel) Injection Concentrate in combination with cisplatin and 5 ...
Taxotere®/Platinol®/Herceptin® Effective in Locally Advanced ... Mar 22, 2006
Cancer Consultants (press release), ...online article published in the Journal of Clinical Oncology, the treatment regimen consisting of Taxotere® (docetaxel), Platinol® (cisplatin) and Herceptin ...
Point Therapeutics to Present at CIBC World Markets Annual ... Mar 29, 2006
Genetic Engineering News, Point is also studying talabostat in several Phase 2 trials, including as a single-agent in metastatic melanoma, in combination with cisplatin in metastatic ...
Pro-Pharmaceuticals Completes Patient Enrollment in Stage 1 of ... Mar 30, 2006
Genetic Engineering News, ...with its lead product candidate, DAVANAT(R), in combination with 5-FU, leucovorin, irinotecan, doxorubicin, oxaliplatin, paclitaxel, cisplatin, and bevacizumab ...
Taxotere (Docetaxel) Receives US FDA Approval For Use In Advanced ... Mar 23, 2006
DG News ...application (sNDA), the US Food and Drug Administration (FDA) has approved Taxotere(R) (docetaxel) Injection Concentrate in combination with cisplatin and 5 ...
MRP2 expression did not correlate with chemotherapy response in ... Mar 23, 2006
Therapeutics Daily (subscription) (press release), According to recent research published in the journal Gynecologic Oncology, "The ABC transporter MRP2 (ABCC2) can mediate cisplatin efflux, and over-expression ...
American Journal of Respiratory and Critical Care Medicine Vol 173 ... Mar 28, 2006
AJRCCM (subscription), ...therapy trial in patients with total resected stage IB or II NSCLC randomized to observation or four cycles of vinorelbine plus cisplatin chemotherapy (31). ...
Gemzar®/Paraplatin® Followed by Taxol®/Paraplatin® as Initial ... Mar 28, 2006
Cancer Consultants (press release), Over the past 10 years, platinum-based chemotherapy regimens (regimens containing carboplatin or cisplatin) have become the mainstay of treatment for women ...
Dangerous glucose-hungry cervical tumors can be detected using PET ... Mar 30, 2006
EurekAlert (press release), ..."Our clinical experience has taught us that standard therapy, which includes both chemotherapy with cisplatin and radiation treatments, doesn't seem to be able ...
Taxotere Receives Positive Opinion from the Committee for ... Mar 24, 2006
PharmaLive.com (press release), Agency has issued a positive opinion recommending approval in Europe of TAXOTERE® (docetaxel) Injection Concentrate in combination with cisplatin and 5 ...
Carbon monoxide: from silent killer to potential remedy Mar 9, 2006
AJP-Renal Physiology 25) have further explored the role of CO, released from a water-soluble, transition metal-containing carbonyl (CORM-3) (4), in cisplatin-mediated renal injury ...
Sanofi's Taxotere wins US FDA approval for advanced stomach cancer ... Mar 23, 2006
Forbes ...breast, lung and prostate cancer, passed a six-month priority review for effectiveness when used in conjunction with the current treatment of cisplatin and 5 ...
Sanofi-aventis Receives FDA Approval For TAXOTERE Injection ... Mar 23, 2006
Trading Markets, ...patients, Sanofi-aventis (SNY | charts | news | Powerrating) on Thursday, announced that it's TAXOTERE Injection Concentrate in combination with cisplatin and 5 ...
Taxotere Receives US FDA Approval For Use In Advanced Stomach ... Mar 24, 2006
Playfuls.com, ...drug application (sNDA), the US Food and Drug Administration (FDA) has approved Taxotere (docetaxel) Injection Concentrate in combination with cisplatin and 5 ...
General Thoracic Surgery Mar 8, 2006
The Journal of Thoracic and Cardiovascular Surgery OBJECTIVE: We sought to investigate whether intrapleural topical application of cisplatin with a surgical carrier has a prolonged local tissue level in ...
Taxotere® Approved for Advanced Gastric Cancer Mar 24, 2006
Cancer Consultants (press release), The indication includes the combination of Taxotere with 5-fluorouracil and cisplatin (Platinol®) in patients with advanced gastric cancer who have not ...
Committee for Medicinal Products for Human Use Post-authorisation ... Mar 24, 2006
PharmaLive.com (press release), The new indication adopted by CHMP is: “Gastric Adenocarcinoma: Taxotere (docetaxel) in combination with cisplatin and 5-fluorouracil is indicated for the ...
Sanofi-Aventis Gets New Taxotere FDA OK Mar 23, 2006
Houston Chronicle, The approval covers the use of Taxotere along with chemotherapy drugs cisplatin and 5-fluorouracil to treat patients with advanced stomach cancer who have not ...
Taxotere OK'd for advanced stomach cancer Mar 23, 2006
United Press International The drug maker said the Food and Drug Administration OK'd Taxotere (docetaxel) Injection Concentrate for use in combination with cisplatin and 5-fluorouracil ...
FDA Approves TAXOTERE® for stomach cancer Mar 25, 2006
Cancerfacts.com, The most common side effects (all grade) associated with the cisplatin and 5-fluorouracil arm were anemia, neutropenia, nausea and vomiting. ...
ADVENTRX Announces Upcoming Scientific Conference Presentations Mar 28, 2006
Yahoo! News (press release) Vinorelbine is a chemotherapeutic agent indicated as a single agent or in combination with cisplatin for treatment of advanced non-small cell lung cancer (NSCLC ...
MultiVu Video Feed: FDA Approves New Treatment For Patients With ... Mar 23, 2006
PR Newswire (press release), 23 /PRNewswire/ -- The US Food and Drug Administration (FDA) has approved TAXOTERE(R) (docetaxel) Injection Concentrate in combination with cisplatin and 5 ...
Alimta® and Paraplatin® Effective and Well-Tolerated in ... Mar 22, 2006
Cancer Consultants (press release), It is indicated for treatment of mesothelioma in combination with the chemotherapy agent Platinol® (cisplatin) among patients who are not eligible for surgery ...
FDA APPROVES NEW TREATMENT FOR PATIENTS WITH ADVANCED STOMACH ... Mar 23, 2006
PR Newswire (press release), The US Food and Drug Administration (FDA) has approved TAXOTERE® (docetaxel) Injection Concentrate in combination with cisplatin and 5-fluorouracil for the ...
Ovarian Cancer Mar 7, 2006
KTEN, ...into the abdomen is re-absorbed into the blood stream with the Cisplating, but you get a huge concentration- 100 fold concentration of Cisplatin bathing the ...
CMPH 20-23 March 2006 Initial Marketing Authorisation Applications ... Mar 25, 2006
Medical News Today (press release), Taxotere (docetaxel), from Aventis Pharma SA, to add the treatment of metastatic gastric adeno-carcinoma in combination with cisplatin and 5-fluorouracil. ...
FDA APPROVES TAXOTERE(R) FOR THE TREATMENT OF PATIENTS WITH ... Mar 24, 2006
PR Newswire (press release), THE US FOOD AND DRUG ADMINISTRATION (FDA) HAS APPROVED TAXOTERE(R) (DOCETAXEL) INJECTION CONCENTRATE IN COMBINATION WITH CISPLATIN AND 5-FLUOROURACIL FOR THE ...
Former Texas Gov. Ann Richards has esophagus cancer Mar 9, 2006
Food Consumer, Chemotherapy depends on the tumor type, but tends to be cisplatin-based (or carboplatin or oxaliplatin) every three weeks with fluorouracil (5-FU) either ...
Less Toxic Chemotherapy Regimen for Metastatic Urothelial Cancer ... Mar 15, 2006
Cancer Consultants (press release), According to the results of a phase II clinical trial published in the journal Cancer, the chemotherapy combination P-HDFL (cisplatin, high-dose 5-fluorouracil ...
UPDATE 2-Sanofi's Taxotere wins backing for approval Mar 24, 2006
Reuters The FDA on Thursday cleared Taxotere injection concentrate in combination with cisplatin and 5-fluorouracil for the treatment of patients with advanced stomach ...
Update 1-Sanofi's Taxotere gets FDA nod for stomach cancer Mar 23, 2006
Reuters Taxotere injection concentrate was approved in combination with cisplatin and 5-fluorouracil for the treatment of patients with advanced stomach cancer ...
FDA Approves ERBITUX(R) (Cetuximab) for Treatment of Head and Neck ... Mar 1, 2006
Genetic Engineering News, The safety of ERBITUX in combination with radiation therapy and cisplatin has not been established. Death and serious cardiotoxicity ...
Sanofi-aventis Reveals US FDA Nod For TAXOTERE For Use In Advanced ... Mar 23, 2006
Trading Markets, Sanofi-aventis (SNY | charts | news | Powerrating) on Thursday said that the US FDA approved TAXOTERE Injection Concentrate in combination with cisplatin and 5 ...
Hana Biosciences to License Three Targeted Cancer Drug Candidates ... Mar 17, 2006
Genetic Engineering News, Vinorelbine (Navelbine(R); GlaxoSmithKline), a microtubule inhibitor, is approved for use as a single agent or in combination with cisplatin for the first ...
Abdominal Chemo Boosts Survival In Ovarian Cancer Patients Mar 10, 2006
eMaxHealth.com, The second chemotherapy agent used in the current study was cisplatin, a drug which most clinicians bypass in favor of carboplatin, a faster and better ...
Pro-Pharmaceuticals' Abstract Accepted for Publication in ASCO ... Mar 17, 2006
International News Service, ...has been conducting clinical and pre-clinical studies with 5-FU, leucovorin, irinotecan, doxorubicin, oxaliplatin, paclitaxel, cisplatin, and bevacizumab ...
Point Therapeutics Reports Fourth Quarter and Year-End 2005 ... Mar 14, 2006
Genetic Engineering News, Demonstrated biological activity in both the single agent talabostat and talabostat in combination with cisplatin Phase 2 studies in metastatic melanoma. ...
Subcutaneous Amifostine Feasible During Radiotherapy for Head and ... Mar 1, 2006
Cancerpage.com, ...retrospectively evaluated 33 consecutive patients treated with accelerated concomitant-boost radiation therapy, 26 of whom also received cisplatin alone or ...
Tomudex® Plus Platinol® and Platinol Alone Reduce Dyspnea in ... Mar 22, 2006
Cancer Consultants (press release), Cancer Group and the National Cancer Institute of Canada have reported that the combination of Tomudex (raltitrexed) and Platinol® (cisplatin) or Platinol ...
YM BioSciences initiates Non-Small-Cell Lung Cancer trial with ... Mar 23, 2006
Yahoo! News (press release) The standard of care for the treatment of NSCLC is radical therapy utilizing the chemotherapy cisplatin in combination with high dose radiation. ...
Tomudex® Plus Eloxatin® Effective in Gemzar®-Resistant ... Mar 24, 2006
Cancer Consultants (press release), Platinum compounds such a Platinol® (cisplatin) and Eloxatin has been combined with Gemzar for the treatment of pancreatic cancer. ...
Sunesis Pharmaceuticals Initiates Phase II Clinical Trial of SNS ... Mar 20, 2006
Yahoo! News (press release) ..."First-line treatment for small cell lung cancer typically involves use of a platinum drug such as cisplatin in combination with a second agent, typically ...
Chemotherapy plus Radiation Therapy Superior to Aggressive ... Mar 7, 2006
Cancer Consultants (press release), This trial included 163 patients who were treated with either chemotherapy, consisting of Platinol® (cisplatin) and 5-flurouracil (5-FU) plus standard ...
Hana Paying Up To $42M For Inex’s Cancer Drugs Mar 17, 2006
BioWorld Online (subscription), Navelbine by GlaxoSmithKline plc, of London, also is a microtubule inhibitor, approved for use as a single agent or in combination with cisplatin for the first ...
Select AIDS, cancer drugs to become cheaper Mar 2, 2006
Sify, Some of the cancer drugs expected to see a downward price revision are cisplatin, cytosine arabinoside, danazol, daunorubicin HCL, etoposide, flutamide ...
MultiVu Video Feed: FDA Approves ERBITUX(R) (Cetuximab) for ... Mar 1, 2006
Finanzen.net, Death and serious heart problems were seen in a clinical trial with ERBITUX and a particular type of radiation and cisplatin (a chemotherapy) treatment regimen ...
FDA Approves ERBITUX(R) (Cetuximab) for Treatment of Head and Neck ... Mar 1, 2006
Finanzen.net, ...cardiotoxicitywere observed in a single-am trial with ERBITUX, delayed, accelerated(concomitant boost) fractionation radiation therapy, and cisplatin(100 mg/m2 ...
Dana Reeve, a Nonsmoker, Dies of Lung Cancer at 44 Mar 7, 2006
MedPage Today, ...radiation. The resection is followed by adjuvant chemotherapy, usually with a cisplatin-based regimen in patients with Stage 1B. ...
American Pharmaceutical Partners Receives 2 Tentative FDA ... Mar 9, 2006
Trading Markets, ...prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin, and prevention ...
Chemotherapy 'Primer' May Help Larynx Cancer Patients Save Voice Mar 13, 2006
ACS News Center, They treated 97 patients with advanced larynx cancer with a single course of chemotherapy with the drugs cisplatin and 5-fluorouracil. ...
Ovarian Cancer and Abdominal Chemo Mar 16, 2006
eMaxHealth.com, ...of the tumor (debulking), followed by six to eight courses of IV chemotherapy given every three weeks with a platinum drug, such as cisplatin or carboplatin ...
Radiation Therapy and Combination Chemotherapy for Head and Neck ... Mar 8, 2006
Cancer Consultants (press release), ...daily. During the first and fourth weeks of radiation therapy, patients also received chemotherapy with fluorouracil and cisplatin. ...
Concurrent Radiation Therapy and Chemotherapy for Small Cell Lung ... Mar 16, 2006
Cancer Consultants (press release), Combination chemotherapy treatment with Vepesid and Platinol® (cisplatin) results in complete remission (CR) in 40-60% of patients. ...
Chemotherapy and Radiation Therapy May Replace Surgery in Early ... Mar 3, 2006
Cancer Consultants (press release), Patients had the earliest stages of esophageal cancer and were treated with the chemotherapy agents Platinol® (cisplatin) and 5-fluorouracil, as well as ...
Erbitux® Plus Chemotherapy and Radiation Therapy Promising in ... Mar 2, 2006
Cancer Consultants (press release), ...recently conducted a clinical trial to evaluate the treatment regimen consisting of Erbitux, radiation therapy, and the chemotherapy agent Platinol® (cisplatin ...
Single hit chemo guides therapy for larynx cancer Feb 27, 2006
Reuters Ninety-seven patients with stage III and IV larynx cancer were given a single cycle of chemotherapy consisting of cisplatin on day 1 and fluorouracil for 5 days ...
Fringe wins for pharma, but cos seek stronger dose Feb 28, 2006
Economic Times, Budget. Some of these drugs are cisplatin, stavudine, danazol and didanosine. However, the industry sees these as minor concessions. ...
New generation gold-based drugs for treating rheumatoid arthriti Feb 27, 2006
News-Medical.net, During their search through thousands of compounds they found that the known cancer drug, Cisplatin, a drug containing the metal platinum, directly stripped ...
Healing’s Golden Touch Explained Feb 26, 2006
Science a Gogo By chance, the team observed that a known cancer drug containing platinum, Cisplatin, stripped the MHC class II protein of all invading molecules. ...
Chemo-related hearing loss a problem for kids Dec 19, 2005
Reuters ...than previously reported in children with cancer who have undergone chemotherapy with highly effective platinum-type drugs such as cisplatin and carboplatin ...
Fluorouracil Inferior to Cisplatin in Cervical Cancer Dec 14, 2005
Cancerpage.com, Reuters Health) - In combination with pelvic radiation, protracted venous infusion of fluorouracil offers no advantages over weekly cisplatin, according to a ...
Cisplatin Nephrotoxicity Is Critically Mediated via the Human ... Dec 9, 2005
Am J Pathology (subscription) Cis-platin is an effective anti-neoplastic agent, but it is also highly nephrotoxic. Here, we clearly identify the human organic ...
Glucocorticoids enhance cytotoxicity of cisplatin via suppression ... Nov 28, 2005
Journal of Endocrinology Glucocorticoids (GCs) are commonly co-administered with cisplatin in the treatment of patients with carcinomas to prevent drug-induced allergic reaction, nausea ...
Recycled Or Revamped Therapeutics Find Novel Anti-cancer ... Nov 20, 2005
Science Daily (press release) Gossypol, once touted as a potential male contraceptive, may find a new use -- helping certain head and neck cancers overcome their resistance to cisplatin. ...
Addition of Taxol® to Chemotherapy Combination Improves Survival ... Nov 29, 2005
Cancer Consultants (press release), ...to a recent article published in the Journal of Clinical Oncology, the addition of the chemotherapy agent Taxol® (paclitaxel) to Platinol® (cisplatin) and 5 ...
Toward The Future Of Cancer Prevention Dec 18, 2005
Science Daily (press release) People with more efficient DNA repair function who were given chemotherapy, particularly platinum-based drugs like cisplatin, had a lower overall survival rate ...
Hearing Loss From Chemotherapy Underestimated Dec 12, 2005
Science Daily (press release) 1986 from the effects of ototoxicity, a condition in which platinum-based chemotherapy drugs, such as carboplatin and the more common cisplatin, damage the ...
Hearing loss from chemo underestimated Dec 13, 2005
myDNA.com, 33, has suffered since 1986 from the effects of ototoxicity, a condition in which platinum-based chemotherapy drugs like carboplatin and cisplatin damage the ...
Chemo After Surgery Extends Life in Advanced Endometrial Cancer Dec 9, 2005
Cancerpage.com, NEW YORK DEC 09, 2005(Reuters Health) - For women with advanced endometrial cancer, the combination of doxorubicin and cisplatin after surgery significantly ...
FDA Grants Priority Review to Taxotere for the Supplemental New ... Dec 2, 2005
PharmaLive.com (press release), ...supplemental new drug application (s-NDA) for Taxotere(R) (docetaxel) Injection Concentrate, in combination with a current standard treatment (cisplatin and 5 ...
Hearing Loss Is Common in Children Treated With Platinum-Based ... Nov 29, 2005
Cancer Consultants (press release), More than half of children treated with the chemotherapy drugs cisplatin or carboplatin experience some degree of hearing loss as a result of treatment ...
Chemotherapy after surgery extends survival for patients with ... Dec 5, 2005
EurekAlert (press release), ...of recurrence and overall survival between 194 women with advanced endometrial cancer who received chemotherapy with the drugs doxorubicin and cisplatin over a ...
Chemotherapy Extends Survival for Endometrial Cancer Patients Dec 7, 2005
Ivanhoe, A new study reveals the drugs doxorubicin and cisplatin reduce the risk of recurrence by 29 percent and extend survival by 32 percent compared to women who had ...
Research Notebook Dec 14, 2005
OregonLive.com, ...say. Hearing loss has long been known to be a side effect of certain chemotherapy drugs, such as cisplatin and carboplatin. Many ...
Intensive Chemotherapy Regimen Shows Promise for Germ Cell Tumors Dec 5, 2005
Cancer Consultants (press release), This regimen consisted of cycles of cisplatin, vincristine, bleomycin, and carboplatin, followed by one cycle of vincristin and bleomycin and three cycles of ...
Induction Chemotherapy and Concomitant Chemoradiotherapy Promising ... Dec 6, 2005
Cancer Consultants (press release), ...reported a 3-year survival rate of 45% in patients with stage III NSCLC treated with induction Gemzar® (gemcitabine) and Platinol® (cisplatin) followed by ...
Human Genome Sciences Reports Interim Results of Phase 1b Clinical ... Nov 17, 2005
PR Newswire (press release), ...a population pharmacokinetic (PK) analysis, to assess the impact of HGS-ETR1 co- administration on plasma concentrations of gemcitabine and cisplatin, and to ...
Two Drugs Boost Endometrial Cancer Survival Dec 6, 2005
ABC News 6 (HealthDay News) — The use of two drugs, doxorubicin and cisplatin, given after surgery, may help women battling advanced endometrial cancer, new research ...
Chemo after surgery extends life in endometrial cancer Dec 9, 2005
Reuters.uk, ...investigators compared recurrence rates and overall survival between 194 women randomized to 5 months of chemotherapy with doxorubicin and cisplatin with that ...
Source: sanofi-aventis Dec 8, 2005
Yahoo! News (press release) ...for the treatment of patients with unresectable locally advanced or metastatic non-small cell lung cancer (NSCLC) in combination with cisplatin, who had not ...
Point Therapeutics Announces Positive Interim Results at American ... Dec 12, 2005
Business Wire (press release), Point is also studying talabostat in several Phase 2 trials, including as a single-agent in metastatic melanoma, in combination with cisplatin in metastatic ...
Trastuzumab Used as First Line Therapy in Women Whose Cancer Has ... Dec 12, 2005
DG News ...real-life" study. Such agents included paclitaxel and docetaxel, vinorelbine, capecitabine cisplatin and doxorubicin. lead author ...
Chemo hearing-loss treatments considered Dec 12, 2005
United Press International ...trial of a second potential chemo-protectant called N-acetylcysteine, or NAC, which may prevent hearing loss by binding to cisplatin's platinum molecules.
Pro-Pharmaceuticals Announces Two International Clinical Sites in ... Dec 13, 2005
Genetic Engineering News, ...has been conducting pre-clinical and clinical studies with 5-FU, leucovorin, irinotecan, doxorubicin, oxaliplatin, paclitaxel, cisplatin, and bevacizumab ...
Points of Pride Dec 9, 2005
MSU Today, MSU researchers developed the platinum-based compounds Cisplatin and Carboplatin, which have saved tens of thousands of lives in the treatment of certain ...
ADVENTRX Announces Positive FDA Pre-IND Meeting Outcome Dec 7, 2005
Biotech Intelligence (press release), Vinorelbine is a chemotherapeutic agent indicated as a single agent or in combination with cisplatin for treatment of advanced non-small cell lung cancer (NSCLC ...
(Euronext Paris) - Transgene : Clinical Pipeline Update Nov 29, 2005
Euronext, This trial is a randomized, open label and controlled study designed to assess the efficacy of TG4010 in combination with cisplatin and gemcitabine compared to ...
Chemotherapy Lengthens Survival in Advanced Endometrial Carcinoma Dec 6, 2005
MedPage Today, 6 - For women with advanced endometrial carcinoma, Adriamycin (doxorubicin) and Platinol (cisplatin) improves survival more than whole-abdominal radiation ...
How the test is performed: Dec 5, 2005
About - News & Issues, Drugs that can increase uric acid measurements include alcohol, ascorbic acid, aspirin, caffeine, cisplatin, diazoxide, diuretics, epinephrine, ethambutol ...
Gold's potential as a cancer treatment and for mending arthritic ... Dec 12, 2005
Mineweb, ...the multi-drug resistance that some tumours have developed and avoids the debilitating side effects of some existing drugs such as the platinum-based cisplatin ...
Organon Enters into Distribution Agreement for Anzemet(R) Dec 5, 2005
PR Newswire (press release), ...prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high dose cisplatin; the prevention ...
Cytokinetics Announces Clinical and Non-Clinical Results for ... Nov 17, 2005
PR Newswire (press release), ...data relating to resistance mechanisms, pharmacodynamic markers, potential therapeutic index and suitability for combination with cisplatin, will also be ...
Sanofi's Taxotere wins US FDA priority review for gastric cancer ... Dec 1, 2005
Forbes ...used for treating breast, lung and prostate cancer, will be studied for its effectiveness when used in conjunction with current treatment of cisplatin and 5 ...
FDA Grants Priority Review for Sanofi Cancer Drug Dec 2, 2005
Business New Jersey (subscription), ...cancer. Sanofi said the FDA has granted a priority review for the drug Taxotere in combination with chemotherapy treatment cisplatin. ...
New Clinical Study of Phenoxodiol as Chemo-sensitizer for ... Nov 28, 2005
Yahoo! News (press release) ...line therapy for non-small cell lung cancer, (iv) as a second-line therapy for non-small cell lung cancer following prior treatment with cisplatin, and (v) for ...
Induction Chemotherapy Promising in Stage III Non-Small Cell Lung ... Dec 2, 2005
Cancer Consultants (press release), ...gemcitabine and vinorelbine. This was followed by oral etoposide and cisplatin given concurrently with radiation therapy. 29 patients ...
Cancer treatment improved by tweaking genes Nov 23, 2005
The California Aggie Online ...switch process. Other anti-cancer agents, such as etoposide, cisplatin and vinblastine were not affected by Ku86 manipulation. The ...
Genetic switch involved in cells' response to radiation therapy ... Nov 20, 2005
Medical News Today (press release), Ku86 had no effect on the radiosensitizing abilities of other anti-cancer agents tested - etoposide, cisplatin and vinblastine. ...
RCT Hires Kurt R. Gehlsen for Its Top Science Job Nov 29, 2005
Genetic Engineering News, ...an early role in the commercial success of some of today's landmark pharmaceuticals and diagnostics, including the anticancer drugs cisplatin and carboplatin ...
Scientific Research Proves Xanthones Kill Cancer Cells and May ... Nov 25, 2005
PR Web (press release), E (one of over 40 Xanthones found in the Mangosteen fruit), was tested against six chemotherapy agents (5 Flouraicil, cisplatin, vincristine, methotrexate ...
International Approvals: Procoralan, H101, AP2573 Nov 21, 2005
Medscape (subscription) ...addition of H101 therapy yielded a 27% increase in overall response rates (complete or partial) compared with fluorouracil plus cisplatin-based chemotherapy ...
MSU research income ranks seventh in US Nov 27, 2005
The State News, ...their earnings. This year, MSU stopped receiving royalties from patents on cisplatin, developed in the 1970s, and carboplatin. The ...
Newsmaker: Stephen J. Lippard / City native wins top science award Nov 27, 2005
Pittsburgh Post Gazette, Professor of Chemistry at MIT, was recognized for his seminal contribution to helping medical researchers, doctors and scientists understand Cisplatin, the anti ...
Human Genome Sciences Reports Results of Phase 1 Clinical Trials ... Nov 17, 2005
PR Newswire (press release), A Phase 1 study of HGS-ETR1, a fully human monoclonal antibody to TRAIL-R1, in combination with gemcitabine and cisplatin in subjects with advanced solid ...
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