celecoxib
information and resources from the National Cancer Institute
celecoxib
A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis. celecoxib
A nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis.
Celebrex
Accel. Approv. (clinical benefit not established) Reduction of polyp number in patients with the rare genetic disorder of familial adenomatous polyposis.
Searle Dec 23 1999
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news articles
Risk of cardiovascular events and celecoxib: a systematic review ... Feb 28, 2006
Journal of the Royal Society of Medicine Design: Systematic review and meta-analysis of randomized double-blind clinical trials of celecoxib of at least 6 weeks' duration and presented data on serious ...
Celecoxib Increases Risk Of Heart Attack, New Study Finds Mar 2, 2006
Medical News Today (press release), A study published in the March issue of the Journal of the Royal Society of Medicine, has found celecoxib increases the risk of a heart attack by over two-fold ...
Unconvincing Pfizer and uncertain crucifixions Mar 30, 2006
Journal of the Royal Society of Medicine Pfizer's response to last month's research paper investigating the risk of myocardial infarction with celecoxib therapy was depressingly predictable. ...
Some Popular Non-aspirin Pain Drugs May Slow Tendon Healing Mar 27, 2006
eMaxHealth.com, He is the abstract's lead author. "Rats treated immediately following surgical repair with COX-2 inhibitors, including Celecoxib (Celebrex) and Valdecoxib ...
Some Pain Medicines May Inhibit Healing Mar 23, 2006
DG News ..."Rats treated immediately following surgical repair with COX-2 inhibitors, including Celecoxib (Celebrex) and Valdecoxib (Bextra), had weaker tendons and a ...
Painkillers effective in patients with dormant inflammatory bowel ... Mar 21, 2006
Xagena.it, Therapy with Celecoxib ( Celebrex ), a COX-2 inhibitor, for up to 14 days did not have a greater relapse rate than placebo in patients with ulcerative colitis ...
Arthritis drug increases risk of heart attacks: study Feb 28, 2006
Stuff.co.nz, Popular common arthritis drug Celecoxib, marketed as Celebrex, increases the risk of heart attacks more than two-fold, a study has found. ...
Scientist urges rethink after secondarthritis drug found to be ... Feb 28, 2006
ic Wales, Research has found that the Cox-2 inhibitor celecoxib, which is used to treat arthritis and acute pain, increases by more than twofold the risk of a heart ...
Medsafe stands by Celebrex despite risk study Feb 28, 2006
Stuff.co.nz, Medsafe, the Ministry of Health's medicines regulatory body, is happy with warning labels on the arthritis drug celecoxib, despite a study showing it increases ...
Pfizer's Celebrex raises heart attack risk -study Feb 28, 2006
Reuters Medical Research Institute in Wellington, said analysis of trials of the Pfizer Inc (PFE.N: Quote, Profile, Research) drug, also known as celecoxib, showed the ...
Study: Celebrex can double heart attack risk Mar 1, 2006
MSNBC Beasley, of New Zealand’s Medical Research Institute in Wellington, said analysis of trials of the Pfizer Inc drug, also known as celecoxib, showed the ...
Pfizer Painkiller’s Bad Data Mar 1, 2006
Red Herring, In the case of Celebrex, a trial called CLASS (Celecoxib Long-term Arthritis Safety Study) has reported that the drug does not cause an increase in major ...
Glucosamine, chondroitin relieve moderate-to-severe osteoarthritis ... Mar 2, 2006
NutraIngredients.com, Placebo (control); glucosamine only (1500 mg daily); chondroitin sulfate only (1200 mg daily); glucosamine and chondroitin sulfate; or celecoxib (200 mg daily ...
Short-term Celebrex seems safe for osteoarthritis Feb 27, 2006
Reuters.uk, NEW YORK (Reuters Health) - The COX-2 inhibitor Celebrex (celecoxib) causes fewer gastrointestinal complications than traditional nonsteroidal anti ...
Painkiller 'may double risk of heart attacks' Feb 28, 2006
Telegraph.co.uk, Celebrex, or celecoxib, is one of a class of drugs called Cox-2 inhibitors which were hailed as a breakthrough in the treatment of severe pain. ...
Analysis: Celebrex ups heart-attack risk Feb 28, 2006
United Press International ...at Celebrex. "Our evidence shows an increased risk of heart attack in patients taking celecoxib," Beasley said. "Drug regulatory ...
Thomson Scientific Names 'Red-Hot' Research Papers of 2005 Mar 20, 2006
International News Service, ...defibrillator for congestive heart failure" 3 SD Solomon, "Cardiovascular risk New England 97 et al. associated with celecoxib Journal of Med. ...
Glucosamine and Chondroitin Come Up Short in Arthritis Relief Mar 7, 2006
Fitcommerce ...glucosamine alone (1500 mg), chondroitin sulfate alone (1200 mg), glucosamine and chondroitin sulfate combined (same doses), a placebo or celecoxib (200 mg). ...
Los 10 artículos más citados en la literatura médica Mar 22, 2006
AZprensa, 3 (97 citas).- SD Solomon, et al., "Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention," New Engl. ...
Meta-Analysis Links Celebrex to Doubling of MI Risk Mar 2, 2006
MedPage Today, New Zealand, March 2-A meta-analysis of 10 published studies has added a new voice to the concern that long-term treatment with Celebrex (celecoxib)--the only ...
Thomson Scientific Names 'Red-Hot' Research Papers of 2005 Mar 20, 2006
PharmaLive.com (press release), ...et al. levels and outcomes after Journal of Med. et al. associated with celecoxib Journal of Med. et al. cholesterol, C-reactive Journal of Med. ...
Further fears over arthritis drug Mar 1, 2006
BBC News, ...as ibuprofen. In 2004 at least 600,000 patients were prescribed Celebrex - which is the brand name for celecoxib - in the UK. But ...
Study Examines Celebrex and Heart Attacks Mar 1, 2006
Newsday, The research was published in the Journal of the Royal Society of Medicine. "Given the popularity of celecoxib (Celebrex) in the treatment of arthritis ... ...
Column overlooked results of arthritis study Mar 12, 2006
Miami Herald, For participants in the mild knee-pain subgroup, celecoxib proved the most effective, significantly reducing pain for 70 percent of those who took it, compared ...
Celebrex 'doubles risk' of heart attack Mar 2, 2006
Australian, ...director Richard Beasley. "Given the popularity of celecoxib (Celebrex) in the treatment of arthritis ... drug regulatory authorities ...
Celebrex Lawsuit Set for Trial in Barbour County Mar 2, 2006
WSFA, Rosie Ware took Celebrex (Celecoxib), a pharmaceutical treatment for joint pain associated with osteoarthritis and other pain-related conditions. ...
Study Finds Celebrex Increases Risk Of Heart Attack Mar 2, 2006
All Headline News ...those of Vioxx. Beasley says, "Given the popularity of celecoxib (Celebrex) in the treatment of arthritis ... drug regulatory agencies ...
New advertising code of conduct established in Vioxx withdrawal ... Mar 9, 2006
Pharmaceutical Business Review In contrast, the withdrawal of Vioxx has led to a severe decline in sales of Pfizer's competitor product Celebrex (celecoxib) and led to a review of the safety ...
Pfizer Disputes New Zealand Celebrex Heart Attack Link Study ... Mar 2, 2006
Best Syndication, The news agency reported that Beasley said "Given the popularity of celecoxib (Celebrex) in the treatment of arthritis … drug regulatory authorities need to ...
Open access for the JRSM Feb 28, 2006
Journal of the Royal Society of Medicine It demonstrates a link between celecoxib and myocardial infarction, a message that underlines the importance of open access to research findings.
Supplements for knee pain may be more popular than effective Mar 14, 2006
Jackson Hole Star-Tribune, ...the knee to one of five groups: to take daily doses of either glucosamine, chondroitin sulfate, both supplements, the arthritis drug Celebrex (celecoxib) or a ...
Celebrex safe for osteoarthritis Mar 1, 2006
News-Medical.net, This latest study, the Successive Celecoxib Efficacy and Safety Study-1 (SUCCESS-1), was conducted in 39 countries with 13,194 patients who had had ...
ExCel Breast Cancer Prevention Study Back On Track Mar 4, 2006
Medical News Today (press release), ExCel was short-circuited before it really got started last year because a study arm included the cox-2 inhibitor celecoxib (Celebrex) that was suddenly pulled ...
Searching for Osteoarthritis Pain Relief? Mar 6, 2006
DailyIndia.com, Many of us know of COX-2 inhibitors but not by this name. Vioxx (refecoxib), Celebrex (celecoxib), and Bextra (valdecoxib) are COX-2 inhibitors. ...
Sports Nutrition Mar 6, 2006
Natural Products Industry Insider, 400 mg/d sodium chondroitin sulfate (as CSb™ BioActive, from Bioiberica SA), both of these treatments administered simultaneously, 200 mg/d celecoxib (a drug ...
Study finds Celebrex doubles heart attack risk Mar 1, 2006
Pharma Times (subscription), ...patients. Celebrex (celecoxib) remains on the market, although its sales have plummeted in the wake of Vioxx' withdrawal. Another ...
Date set for first Celebrex trial Feb 28, 2006
Pharma Times (subscription), ...has set the date for what could be the first trial in the USA against Pfizer's blockbuster painkiller, the COX-2 inhibitor Celebrex (celecoxib), according to ...
Massive meta analysis clarifies cardiovascular safety of celecoxib ... Nov 22, 2005
Medical News Today (press release), The COX-2 specific inhibitor celecoxib (Celebrex) is not associated with an increased risk of serious cardiovascular thrombotic events compared to placebo or ...
Clinical trial on painkillers Dec 20, 2005
The News Journal, The trial will focus on three drugs -- ibuprofen (Advil/Motrin), naproxen (Naprosyn or Aleve) and celecoxib (Celebrex) -- all of which belong to the class of ...
Pfizer To Finance Long-Term Safety Study Of Celebrex Estimated To ... Dec 14, 2005
About - News & Issues, The worldwide study has been named the PRECISION Trial – Prospective Randomized Evaluation of Celecoxib Integrated Safety vs. Ibuprofen or Naproxen. ...
Painkiller Study Aims to Answer Safety Questions Dec 14, 2005
MedPage Today, ...of 20,000 arthritis patients. The drugs are Celebrex (celecoxib), Motrin (ibuprofen) and Aleve (naproxen). The trial, which could ...
Pfizer Plans Study of Celebrex for Heart Risks, Clinic Says Dec 13, 2005
Bloomberg Sales of Celebrex, also known as celecoxib, fell 45 percent in the first nine months of this year from a year earlier as US regulators issued public warnings. ...
Major Painkiller Trial to Start Dec 15, 2005
ABC News The trial will focus on three drugs — ibuprofen (Advil/Motrin), naproxen (Naprosyn or Alleve) and celecoxib (Celebrex) — all of which belong to the class ...
Clinic to lead trial of painkilling drugs Dec 13, 2005
Crain's Cleveland Business, Dubbed the Precision Trial, the study will examine the safety of ibuprofen, marketed as Motrin; naproxen, known as Naprosyn or Aleve; and celecoxib, also known ...
Pfizer to fund safety study of Celebrex Dec 14, 2005
New Ratings ...a cardiologist at the Cleveland Clinic, will head the study, which will be called PRECISION (Prospective Randomized Evaluation of Celecoxib Integrated Safety ...
Strange Goings On at the Cleveland Clinic: Mere Coincidences or ... Dec 19, 2005
Newsinferno.com, The Celebrex study will be called PRECISION, for Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen. ...
Toward The Future Of Cancer Prevention Dec 18, 2005
Science Daily (press release) Celecoxib, a non-steroidal anti-inflammatory drug (NSAID) known by the trade name Celebrex®, reduced the number of colon polyps in people who have familial ...
Huge study to test safety of painkillers Dec 13, 2005
Houston Chronicle, The study will be called PRECISION, for Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen. ...
Pfizer Plans Study of 20,000 Patients on Risks of Celebrex Dec 13, 2005
New York Times, ..."This could show that celecoxib is the best drug or the worst drug," said Dr. Steven E. Nissen, lead investigator for the study, referring to Celebrex. ...
Pfizer will fund clinic's study on heart risks of Celebrex Dec 13, 2005
Minneapolis Star Tribune (subscription), Sales of Celebrex, also known as celecoxib, fell 45 percent in the first nine months of this year from a year earlier, as regulators issued warnings. ...
Pfizer to Finance $100 Million Safety Study of Celebrex Dec 13, 2005
New York Times, ...patients. "This could show that celecoxib is the best drug or the worst drug," said Dr. Nissen, using the generic name for Celebrex. ...
Researchers Say Estrogen Can Kill Breast Cancer Cells Once Fueled ... Dec 7, 2005
Science Daily (press release) Celecoxib Shows Surprising Activity Against Estrogen Receptors (December 23, 2004) -- Six months of treatment with celecoxib (Celebrex) in women at risk of ...
Study aims to clear up confusion on painkillers Dec 13, 2005
Pittsburgh Post Gazette, Earlier this year, the US Food and Drug Administration directed that those drugs, also known as ibuprofen, naproxen and celecoxib, carry warnings for potential ...
Pfizer sponsors major Celebrex safety study Dec 15, 2005
Pharma Times (subscription), Pfizer is gambling on a 20,000-patient study that it hopes will prove once and for all that its COX-2 inhibitor Celebrex (celecoxib) is effective and no more ...
: Chondroitin Better than Placebo: New Analysis of 30 Studies Dec 13, 2005
NewsReleaseWire.com (press release) ...symptoms. In general, the chondroitin sulfate response within this group was shown to be very similar to that seen with celecoxib. ...
Joint-pain pills studied Nov 22, 2005
Asbury Park Press, The study compared pain relief for patients with osteoarthritis of the knee who took either placebos, the widely prescribed drug celecoxib (sold as Celebrex ...
NSAIDs Ups Risk of Dying After a Myocardial Infarction: Presented ... Nov 22, 2005
DG News Their results show that 5.2% of patients had prescriptions for rofecoxib, 4.3% celecoxib, 17.5% ibuprofen, 10.6% diclofenac, and 12.7% had taken other NSAIDs. ...
A Healthy You: Popular supplements show little effect on arthritis ... Nov 23, 2005
NewsOK.com (subscription), There were five arms to the study: each patient was randomly assigned to either glucosamine, chondroitin, both together, the pain pill celecoxib, or a dummy ...
Consumer Reports Medical Guide & Consumer Reports: Prescription ... Dec 5, 2005
U.S. Newswire (press release), The 12 drugs include: Celecoxib (Celebrex), a pain reliever; Estrogen alone (Premarin and others) or with progestin (Prempro and others) to treat symptoms of ...
New Study Finds COX-2 Inhibitors Are Not Safer for the Stomach Dec 5, 2005
Newsinferno.com, ...and rofecoxib (Vioxx), and diclofenac (Voltaren). T he risk was slightly lower for celecoxib (Celebrex). Celebrex is the only COX ...
Media Coverage of Landmark NIH Study Neglects Important Benefits ... Dec 7, 2005
PR Newswire (press release), ...osteoarthritis pain who received a combination of glucosamine and chondroitin experienced pain relief as compared to 69 percent who took celecoxib and 54 ...
Pharmacyclics Announces Presentation and Published Abstracts on ... Dec 6, 2005
PR Newswire (press release), ...with Inhibitors of Akt Phosphorylation Abstract #4296 Title: Growth Inhibition or Apoptosis after Treatment with Motexafin Gadolinium and Celecoxib Is Cell ...
No Evidence That COX-2 Inhibitors Provide Greater Stomach ... Dec 5, 2005
Medical News Today (press release), ...reduced after adjusting for other factors, but remained significantly increased for naproxen, diclofenac, and rofecoxib, but not for current use of celecoxib. ...
No evidence that COX-2 inhibitors provide greater gastroprotection Dec 9, 2005
Xagena.it, ...increased for Naproxen ( Aleve/Naprosyn ), Diclofenac ( Cataflam/Voltaren ), and Rofecoxib ( Vioxx ), but not for current use of Celecoxib ( Celebrex ). ...
Visiting Veterinarian: Arthritis pain relief for Rover Dec 7, 2005
Martha's Vineyard Times, The equivalent human products are drugs like celecoxib (Celebrex), rofecoxib (Vioxx), and valdecoxib (Bextra.) But wait, you say. ...
Positive Results for Chondroitin Sulfate and the Treatment of ... Nov 21, 2005
PharmaLive.com (press release), ...criteria, the result was that in the overall population, chondroitin sulfate and glucosamine did not outperform the positive control celecoxib, or were not ...
Cox-2 Inhibitors Not Safer for Stomach Dec 1, 2005
Forbes ...diclofenac (Voltaren) and rofecoxib (Vioxx). However, the risk was slightly reduced for celecoxib (Celebrex). Celebrex is the only ...
Cox-2 Inhibitors Not Safer for Stomach Dec 2, 2005
ABC News NSAIDs naproxen and diclofenac (Voltaren). However, the risk was slightly reduced for celecoxib (Celebrex). Celebrex is the only ...
US: News for 21 Million Osteoarthritis Sufferers Nov 21, 2005
TheMatureMarket.com, ...or daily doses of 1,500/mg of glucosamine hydrochloride and/or 1,200 mg of chondroitin sulfate or 200 mg of the common prescription pain medication celecoxib. ...
Two dietary supplements shown to relieve knee pain Dec 3, 2005
Newstarget.com, The study showed that celecoxib reduced knee pain to a lesser extent, but Schumacher recommends the supplements over Celebrex, which carries warnings about ...
Columbia researchers find herbal extract aids in fight against ... Nov 27, 2005
Newstarget.com, ...value for prostate cancer patients, but data from recent trials of selective COX-2 inhibitors such as sulindac (Clinoril®) and celecoxib (Celebrex®), suggest ...
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