carmustine
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NCI Thesaurus | carmustine
An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. NCI Thesaurus | carmustine
An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily.
BCNU, BiCNU Bristol-Myers Squibb Mar 07 1977
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news articles
Carmustine Implant Improves Malignant Glioma Survival Mar 30, 2006
Cancerpage.com, NEW YORK MAR 29, 2006 (Reuters Health) - Placement of a biodegradable polymer containing 3.85% carmustine, the Gliadel wafer (MGI PHARMA) in the resection ...
Gliadel® Wafer Improves Survival in Aggressive Gliomas Mar 30, 2006
Cancer Consultants (press release), ...of cancer. The Gliadel wafer is a thin, coin-sized “wafer� that contains the chemotherapy agent carmustine (BiCNU®). It is ...
Leeds actress lands role in The Producers Mar 18, 2006
Leeds Today, The National Institute of Health and Clinical Excellence (NICE) is looking at the use of carmustine implants and temozolomide in newly-diagnosed patients with ...
Gliadel(R) Wafer Demonstrates Long-Term Survival Benefit for ... Mar 8, 2006
Genetic Engineering News, Gliadel Wafer (polifeprosan 20 with carmustine implant) is a biodegradable wafer containing the chemotherapy agent carmustine, or BCNU, and is indicated in ...
MGI PHARMA Announces Initiation of Aquavan(R) Injection Pivotal ... Mar 20, 2006
Genetic Engineering News, MGI PHARMA markets Aloxi(R) (palonosetron hydrochloride) Injection and Gliadel(R) Wafer (polifeprosan 20 with carmustine implant) in the United States. ...
Temodar® and Thalomid® Effective for Metastatic Neuroendocrine ... Mar 21, 2006
Cancer Consultants (press release), Chemotherapy response rates are low and some of the agents studied include 5-fluorouracil, BiCNU® (carmustine), CeeNU® (lomustine), doxorubicin, dacarbazine ...
MGI Pharma's Gliadel Wafer Demonstrates Long-term Survival Benefit ... Mar 8, 2006
Trading Markets, Gliadel Wafer is a biodegradable wafer containing the chemotherapy agent carmustine and is the only FDA approved brain cancer treatment capable of providing ...
High-Dose Therapy Does Not Improve Multiple Myeloma Outcome Mar 9, 2006
Cancerpage.com, They received melphalan and total-body irradiation and allotransplantation or standard chemotherapy with vincristine, carmustine, cyclophosphamide, melphalan ...
US Study Fails to Confirm Benefits of Autologous Stem Cell ... Mar 14, 2006
Cancer Consultants (press release), ...of responding patients to high-dose therapy with melphalan and TBI (n=258) or continued treatment with vincristine, carmustine, melphalan, cyclophosphamide and ...
MGI PHARMA Provides Update on Aquavan(R) Injection Program; Top ... 21 Dec 2005
Business Wire (press release), MGI PHARMA markets Aloxi(R) (palonosetron hydrochloride) injection and Gliadel(R) Wafer (polifeprosan 20 with carmustine implant) in the United States. ...
View Profiles of 165 Companies Involved in Developing Innovative ... Dec 15, 2005
PharmaLive.com (press release), ...experimental and clinical. Biodegradable implants of carmustine are already used in the treatment of malignant brain tumors. The market ...
NeoPharm Announces Completion of PRECISE Trial Enrollment as Per ... Dec 9, 2005
Genetic Engineering News, A GLIADEL(R) Wafer delivers BCNU (or carmustine), a commonly used chemotherapeutic anti-tumor agent for GBM, directly to the brain tumor resection cavity. ...
Dacogen(TM) (Decitabine) Injection Complete Response Accepted for ... Dec 15, 2005
Yahoo! News (press release) MGI PHARMA markets Aloxi® (palonosetron hydrochloride) injection and Gliadel® Wafer (polifeprosan 20 with carmustine implant) in the United States. ...
Age Makes Little Difference in Outcomes for Non-Hodgkin's Lymphoma ... Dec 12, 2005
DG News ...lymphoma who relapsed and underwent autologous stem cell transplant following BEAM conditioning, which combines BCNU (carmustine), etoposide, cytosine ...
Breakthrough Cancer Treatment Approved in Scotland but Still not ... Dec 12, 2005
PR Newswire UK (press release), Gliadel Implant is an innovative chemotherapy (carmustine) treatment in the form of small 5 pence-sized biodegradable discs that are inserted into the tumour ...
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