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carboxypeptidase-G2
carboxypeptidase-G2
information and resources from the National Cancer Institute
NCI Thesaurus | carboxypeptidase-G2
A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because carboxypeptidase-G2 rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for carboxypeptidase-G2-catalyzed activation of a co-administered prodrug at the site of the tumor.NCI Thesaurus | carboxypeptidase-G2
A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because carboxypeptidase-G2 rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for carboxypeptidase-G2-catalyzed activation of a co-administered prodrug at the site of the tumor.
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carboxypeptidase-G2
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