azacitidine
information and resources from the National Cancer Institute
azacitidine
A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity.azacitidine
A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity.
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news articles
Pharmion Corporation Announces Submission of Vidaza NDA Supplement ... Mar 30, 2006
PR Newswire (press release), About Vidaza On May 19, 2004, Vidaza (azacitidine for injectable suspension) became the first drug approved by the US Food and Drug Administration (FDA) for ...
Globe and Mail Update Mar 11, 2006
Globe and Mail, One, azacitidine or Vidaza, has been approved in the United States, but not yet in Canada. So far, however, it is not a miracle drug. ...
Azacitidine (Vidaza) for Myelodysplastic Syndromes (MDS) Does Not ... Dec 13, 2005
DG News ATLANTA, GA -- December 13, 2005 -- Azacitidine (Vidaza) treatment for myelodysplastic syndromes (MDS) does not increase the rate of infection or bleeding ...
Azacitidine (Vidaza) Is First Drug to Show Survival Benefit in ... Dec 12, 2005
DG News ...higher percentage of elderly patients with high-risk myelodysplastic syndromes (MDS) who received treatment with injectable azacitidine (Vidaza) were alive ...
Clinical Data on Vidaza (Azacitidine for Injectable Suspension) in ... Dec 12, 2005
PharmaLive.com (press release), The concentration of azacitidine required for maximum inhibition of DNA methylation in vitro does not cause major suppression of DNA synthesis. ...
Source: Pharmion Corporation Dec 8, 2005
Yahoo! News (press release) ...poster sessions: Analysis of Survival, AML Transformation, and Transfusion Independence in Patients with High-Risk MDS Receiving Azacitidine Determined Using a ...
MethylGene Reports Encouraging Preliminary Clinical Results for ... Dec 8, 2005
CCNMatthews (press release), MethylGene is also exploring combination Phase I/II trials using MGCD0103 with other chemotherapeutics such as azacitidine (Vidaza TM ), a demethylating agent ...
(PRN) - ATCT Announce the Addition of Michael Nurse to the Board ... Dec 8, 2005
Bolsamania.com, ...[+]. (PRN) - SPOYLT Debuts the First Online Wedding Registry for Lingerie ... [+. PRN) - Clinical Data on Vidaza(R) (Azacitidine for Injectable Suspension) in ...
Telik's TELINTRA Demonstrates Positive, Clinically Significant ... Dec 11, 2005
Yahoo! News (press release) Most patients had failed one or more prior treatments including: 5-azacitidine, lenalidomide, thalidomide, other chemotherapeutic drugs, immune modulators ...
'I'm not interested in quality of life' Dec 7, 2005
Guardian Unlimited, In fact, during their second meeting, Nimer had offered the option of treatment with a drug called 5-azacitidine that gave many MDS patients some months during ...
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