anastrozole
information and resources from the National Cancer Institute
NCI Thesaurus | anastrozole
A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, anastrozole may inhibit tumor growth. NCI Thesaurus | anastrozole
A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, anastrozole may inhibit tumor growth.
Arimidex
Accel. Approv. (clinical benefit not established) for the adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer
AstraZeneca Sep 05 2002
Arimidex
For first-line treatment of postmenopausal women with hormone receptor positive or hormone receptor unknown locally advanced or metastatic breast cancer.
AstraZeneca Pharmaceuticals Sep 01 2000
Arimidex
Treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.
AstraZeneca Pharmaceuticals Dec 27 1995
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news articles
A 62-Year-Old Woman With a New Diagnosis of Breast Cancer Mar 21, 2006
Journal of American Medical Association (subscription), The nonsteroidal compounds anastrozole and letrozole are reversible inhibitors of aromatase, while the steroidal agent exemestane is an irreversible ...
New findings in breast cancer therapy described Mar 30, 2006
Therapeutics Daily (subscription) (press release), The third-generation aromatase inhibitors (AIs) anastrozole, exemestane, and letrozole offer new treatment options, although their efficacy has not been ...
More Routine Monitoring of Bone Density, Preventive Management ... Mar 23, 2006
DG News Results show that early breast cancer -- whether treated early with anastrozole or not -- was associated with an increased risk of fracture. ...
Women wanted for trial of breast cancer drug Mar 9, 2006
Glasgow Evening Times, ...drug. Researchers want to find out whether the drug Anastrozole can reduce the risk of being struck down by the disease. Professor ...
Healthy woman's cancer trial intrigue Mar 5, 2006
ic Wales, ...and grandmother-of-three, is helping to advance the fight against breast cancer by her involvement in the Ibis II trial to test the drug anastrozole. ...
Neoadjuvant Aromatase Inhibitors May Be as Effective as ... Mar 27, 2006
DG News The 121 patients treated with aromatase inhibitors were further randomised to receive either 1 mg daily of anastrozole (61 patients), or 25 mg of exemestane ...
Updated Guidelines for Treatment of Ovarian Cancer Mar 27, 2006
Cancer Consultants (press release), The list of treatment options for recurrent ovarian cancer was broadened to include Arimidex® (anastrozole), Avastin® (bevacizumab), Camptosar® (ironotecan ...
Femara® Approved In Germany As Initial Therapy For Postmenopausal ... Mar 25, 2006
Medical News Today (press release), ...risk, Novartis has initiated the FACE (Femara vs. Anastrozole Clinical Evaluation) trial. This is the first comparative study of ...
Gran on Cancer Frontline Mar 7, 2006
International News Service, ...who lives near Merthyr Tydfil, is helping to advance the fight against breast cancer with her involvement in the Ibis II trial to test the drug Anastrozole. ...
Novartis to compare cancer drug Femara with AstraZeneca drug Mar 20, 2006
MarketWatch ...heads Novartis' oncology division. The acronym FACE stands for Femara versus Anastrozole Clinical Evaluation. In an interview with ...
New Data Show Zometa Increased Bone Mineral Density in Breast ... Mar 22, 2006
PharmaLive.com (press release), ...in premenopausal women with hormone-responsive breast cancer receiving combination endocrine treatment (goserelin and tamoxifen or goserelin and anastrozole). ...
Switching to Arimidex® Reduces Need for Invasive Diagnostic ... Mar 9, 2006
Cancer Consultants (press release), ...breast cancer patients with uterine abnormalities related to Nolvadex® (tamoxifen), switching to the aromatase inhibitor Arimidex® (anastrozole) reduced the ...
New Drugs For Breast Cancer 21 Dec 2005
WFtv.com, ...estrogen. There are three AIs approved by the FDA including anastrozole (Arimidex), exemestane (Aromasin) and letrozole (Femara). ...
More Women Will Survive Breast Cancer With Arimidex (anastrozole) ... Dec 9, 2005
Finanzen.net, LONDON, December 9 /PRNewswire/ -- Breakthrough data show that Arimidex (anastrozole) is the first and only breast cancer drug in the 'aromatase inhibitor' (AI ...
ARIMIDEX (anastrozole) Featured in Studies Evaluating Impact of ... Dec 9, 2005
PharmaLive.com (press release), PRNewswire-FirstCall/ -- Studies presented today at the San Antonio Breast Cancer Symposium analyze the AstraZeneca drug ARIMIDEX(R) (anastrozole) in terms of ...
Fewer Gynecological Problems Seen in Women on Anastrozole in ATAC ... Dec 12, 2005
DG News SAN ANTONIO, TX -- December 12, 2005 -- A landmark trial comparing the efficacy of anastrozole and tamoxifen in preventing recurrence of breast cancer found ...
Survival Advantage of Anastrozole over Tamoxifen Seen in Meta ... Dec 12, 2005
DG News For the first time, doctors say that switching a breast cancer patient from the gold standard tamoxifen to the aromatase inhibitor anastrozole (Arimidex) can ...
No Differences in Time to Response for Fulvestrant and Anastrozole ... Dec 13, 2005
DG News SAN ANTONIO, TX -- December 13, 2005 -- Doctors said that treatment with daily oral anastrozole or a once-monthly injection with fulvestrant showed no ...
Anastrozole (Arimidex) Outperforms Tamoxifen Dec 5, 2005
CancerWise The drug anastrozole (Arimidex®) now replaces tamoxifen as the recommended treatment to help prevent recurrence of breast cancer in postmenopausal women with ...
Five-Year Data from Austrian Trial Shows Significant Benefit in ... Dec 14, 2005
DG News Cancer Study Group trial 8 (ABCSG-8) show a significant benefit among women with breast cancer who take tamoxifen for 2 years and then switch to anastrozole. ...
New Data Show Survival Benefit for Arimidex(TM) in Early Breast ... Dec 9, 2005
news aktuell (Pressemitteilung), Macclesfield, England (ots/PRNewswire) - - Replacing tamoxifen With Arimidex (TM) (anastrozole) Shown to Reduce Patient's Risk of Death by Nearly a Third ...
New Data Show Survival Benefit for Arimidex(TM) in Early Breast ... Dec 9, 2005
PR Newswire (press release), ...- Replacing tamoxifen With Arimidex(TM) (anastrozole) Shown to Reduce Patient's Risk of Death by Nearly a Third MACCLESFIELD, England, Dec. ...
New Data Show Survival Benefit for Arimidex(TM) in Early .... Dec 9, 2005
Nieuwsbank (persbericht), Breakthrough new data presented today show breast cancer treatment 'Arimidex' (anastrozole) is the first aromatase inhibitor (AI) to provide an overall ...
Breast cancer drug may work in lung cancer Dec 16, 2005
Science Daily (press release) 16 (UPI) -- Breast cancer drug Anastrozole, sold as Arimidex, may also inhibit the growth of lung cancer, say researchers at Vanderbilt University in the ...
Breast cancer drug may work in lung cancer Dec 16, 2005
Monsters and Critics.com, WASHINGTON, DC, United States (UPI) -- Breast cancer drug Anastrozole, sold as Arimidex, may also inhibit the growth of lung cancer, say researchers at ...
Plenary Session Snapshot Dec 19, 2005
Medscape (subscription) ...it. Arimidex (anastrozole) is one of these agents. ... radiation. They did receive hormonal treatment with either tamoxifen or anastrozole. ...
Breast cancer drugs for lung cancer? Dec 18, 2005
myDNA.com, The team treated its cells with the drug anastrozole for 48 hours, finding that it did in fact shut down aromatase activity and retard tumor growth in the lab. ...
Survival Benefit For Arimidex™ In Early Breast Cancer Dec 11, 2005
Medical News Today (press release), Data presented at the San Antonio Breast Cancer Symposium (SABCS), Texas has found that 'Arimidex' (anastrozole) is the first aromatase inhibitor (AI) to ...
NHS under pressure to provide new breast cancer drugs Dec 12, 2005
News-Medical.net, The combined results from three European trials of anastrozole, one of the new drugs, suggests that postmenopausal women who switched from Tamoxifen two years ...
New cancer drug puts NHS under pressure Dec 9, 2005
Guardian Unlimited, Pooled results from three European trials of anastrozole, one of the new drugs, suggested that postmenopausal women who switched from tamoxifen two years into ...
SABCS: A Switch to Arimidex After Two Years of Tamoxifen Improves ... Dec 10, 2005
MedPage Today, ...breast cancer therapy can improve their chances of a lengthy survival by 29% if they switch to the aromatase inhibitor Arimidex (anastrozole) after two or ...
Survival gain seen with breast-cancer drug Dec 9, 2005
United Press International ...and one Austrian study that compared outcomes between postmenopausal women taking either tamoxifen or the aromatase inhibitor anastrozole (Arimidex) following ...
Data Show Survival Benefit For Arimidex In Early Breast Cancer Dec 9, 2005
PharmaLive.com (press release), Data presented today at the San Antonio Breast Cancer Symposium (SABCS), Texas has found that 'Arimidex' (anastrozole) is the first aromatase inhibitor (AI) to ...
Breakthrough survival data on Arimidex® released Dec 11, 2005
Scoop.co.nz (press release), The results of the latest study, carried out in women who had already taken tamoxifen for two years, show that replacing tamoxifen with anastrozole for the ...
Study Confirms Superiority of Switching to Arimidex® Following 2 ... Dec 12, 2005
Cancer Consultants (press release), A meta-analysis from three large randomized trials has confirmed that switching to the aromatase inhibitor Arimidex (anastrozole) following 2-3 years of ...
NHS pressured to approve new cancer drug Dec 11, 2005
FemaleFirst.co.uk, He said 90 out of the 1,997 women taking tamoxifen in the studies died, compared with 66 women out of 2,009 who were taking anastrozole in the studies. ...
Analysis Demonstrates Time to Response With FASLODEX(R) ... Dec 10, 2005
PR Newswire (press release), ...analysis of two Phase III studies evaluating time to response (TTR) with FASLODEX(R) (fulvestrant) Injection compared to ARIMIDEX(R) (anastrozole) as treatment ...
Benefit of Switching to Arimidex® After 2-3 Years of Tamoxifen ... Dec 13, 2005
Cancer Consultants (press release), A combined analysis of three large clinical trials has confirmed that switching to the aromatase inhibitor Arimidex (anastrozole) after 2-3 years of adjuvant ...
(PRN) - Creighton Corp. Completes Merger with Pearlstar ... Dec 9, 2005
Bolsamania.com, ...[+]. (PRN) - ARIMIDEX(R) (anastrozole) Featured in Studies Evaluating Impact of Switching on Survival in Adjuvant Treatment of Early Breast Cancer ... [+. ...
Breast Cancer Treatment Dec 16, 2005
Food Consumer, Arimidex, tamoxifen alone or in combination.: Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of ...
NHS under pressure to broaden access for new breast cancer drug Dec 11, 2005
viploan.co.uk, ..."Survival is the ultimate goal in the treatment of early breast cancer, and these results provide compelling evidence that anastrozole has the potential to ...
Femara gets approval for early adjuvant use in UK Dec 8, 2005
Pharma Times (subscription), This profile should aid Femara as it competes with the other main aromatase inhibitors, AstraZeneca's Arimidex (anastrozole) and Pfizer's Aromasin (exemestane ...
New cancer drug puts pressure on NHS Dec 12, 2005
myDNA.com, ...study involving 4,000 postmenopausal women with hormone-sensitive early breast cancer found that those who were treated with Arimidex (anastrozole) instead of ...
Switch from Tamoxifen to Letrozole Results in Significant ... Dec 12, 2005
DG News As part of the Anastrozole or Tamoxifen, Alone or in Combination (ATAC) trial a sub-group of 107 women who took part in an open label cross-over study were ...
SABCS: Ki67 Level Two Weeks After Starting Arimidex Predicts ... Dec 10, 2005
MedPage Today, 10 - Within two weeks of starting treatment with the aromatase inhibitor Arimidex (anastrozole) as adjuvant therapy for breast cancer, a well-known cellular ...
AstraZeneca Provides Additional Support to Hurricane Victims Nov 17, 2005
PR Newswire (press release), These medicines include: ACCOLATE(R) (zafirlukast), ARIMIDEX(R) (anastrozole), ATACAND(R) (candesartan cilexetil), ATACAND HCT(R) (candesartan cilexetil ...
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