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XRP9881
XRP9881
information and resources from the National Cancer Institute
NCI Thesaurus | XRP9881
A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic properties. XRP9881 binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. XRP9881 penetrates the blood brain barrier. NCI Thesaurus | XRP9881
A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic properties. XRP9881 binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. XRP9881 penetrates the blood brain barrier.
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XRP9881
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