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Thiofozil
Thiofozil
information and resources from the National Cancer Institute
Thiofozil
(Other name for: thiotepa)thioguanine
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. Thiofozil
(Other name for: thiotepa)
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Thiofozil
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