TISSEEL
information and resources from the National Cancer Institute
TISSEEL
(Other name for: fibrin sealant)TLK286
A modified glutathione analog. TLK286 is selectively activated by glutathione S-Transferase P1-1 into an alkylating metabolite which forms covalent linkages with nucleophillic centers in tumor cell DNA, thereby inducing a cellular stress response and cytotoxicity, and decreasing tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies. TISSEEL
(Other name for: fibrin sealant)
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news articles
Baxter and Kuros Announce Product License and Collaboration ... Nov 17, 2005
PR Newswire (press release), These products will be based on Baxter's fibrin-based biomatrix, TISSEEL(R) Fibrin Sealant, combined with Kuros' proprietary biologics and associated binding ...
Baxter and Kuros Announce Product License and Collaboration ... Nov 17, 2005
PR Newswire (press release), These products will be based on Baxter's fibrin-based biomatrix, TISSEEL(R) Fibrin Sealant, combined with Kuros' proprietary biologics and associated binding ...
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