S-1
information and resources from the National Cancer Institute
NCI Thesaurus | S-1
An oral fluoropyrimidine antagonist composed of tegafur combined with two modulators of 5-flurouracil (5-FU) activity, 5-chloro-2,4-dihydroxypyridine (CDHP) and potassium oxonate, in a molar ratio of 1:0.4:1. Tegafur is a prodrug of 5-fluorouracil, an antimetabolite that inhibits thymidylate synthase, thereby inhibiting DNA synthesis and cell division, and competes with uridine triphosphate, thus inhibiting RNA and protein synthesis. CDHP is a reversible inhibitor of dihydropyrimidine dehydrogenase (DPD), the liver enzyme responsible for rapid catabolism of 5-FU into inactive metabolites. Potassium oxonate preferentially localizes in the gut and inhibits the enzyme orotate phosphoribosyltransferase (the major enzyme responsible for 5-FU activation), thereby decreasing activation of 5-FU in the gut and activated 5-FU-related gastrointestinal toxicity. NCI Thesaurus | S-1
An oral fluoropyrimidine antagonist composed of tegafur combined with two modulators of 5-flurouracil (5-FU) activity, 5-chloro-2,4-dihydroxypyridine (CDHP) and potassium oxonate, in a molar ratio of 1:0.4:1. Tegafur is a prodrug of 5-fluorouracil, an antimetabolite that inhibits thymidylate synthase, thereby inhibiting DNA synthesis and cell division, and competes with uridine triphosphate, thus inhibiting RNA and protein synthesis. CDHP is a reversible inhibitor of dihydropyrimidine dehydrogenase (DPD), the liver enzyme responsible for rapid catabolism of 5-FU into inactive metabolites. Potassium oxonate preferentially localizes in the gut and inhibits the enzyme orotate phosphoribosyltransferase (the major enzyme responsible for 5-FU activation), thereby decreasing activation of 5-FU in the gut and activated 5-FU-related gastrointestinal toxicity.
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news articles
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Full Text Mar 9, 2006 Science Magazine (subscription) ...described previously (7, 8). H 2 CO was excited into specific vibrational and rotational states (v, J, Ka , Kc ) in the first excited singlet state (S 1 , 1 A ...
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Directed Electronics Reports Record Fourth Quarter and Full Year ... Mar 30, 2006 PR Newswire (press release), ...are discussed from time to time in the reports filed by Directed with the Securities and Exchange Commission, including the Form S-1. Directed disclaims any ...
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West Chester University $ 3, University of North Dakota 2 Mar 13, 2006 UND Fighting Sioux, Ryan Gerber W,1-2..... 6.0 7 2 2 3 4 0 0 3 0 24 31 7 6 Mark Rubini S,1..... 1.0 1 0 0 0 0 0 0 0 0 3 3 1 1 HBP - by Bostelman (WHITE, B.). Strikeouts ...
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Jimenez boots Bronchos closer to postseason Mar 18, 2006 Odessa American, In Tuesday’s 1-0 victory against Abilene High, David Torres scored with his back to the goal with less than 10 minutes to play for the Bronchos. ...
Northeastern 3, Central Michigan 1 Mar 5, 2006 Northeastern Huskies, 2/cf ALLEN, Cody; 9/rf JONES, JT; 6/2b MORATTI, T.; 28/1b HUMPHREY, B.; 25/lf MITZEL, B.; 4/dh LANKFORD, N.; 12/c STOVALL, T.; 10/3b SZPYRKA, S.; 1/ss RESNICK ...
UNH comes up empty Mar 25, 2006 Boston Herald, ...“It’s an unbelievable feeling to be here and win the game,� Lerg said. “I’ll do whatever it takes to win, whether it’s 1-0, 2-1 or a 6-5 shootout. ...
NTELOS Holdings Corp. Reports Fourth Quarter and Full Year 2005 ... Mar 21, 2006 MSN Money Holdings Corp. Prospectus (Form S-1) dated February 8, 2006 for details related to the formation of NTELOS Holdings Corp. and a ...
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NEW ORLEANS BOWL SOUTHERN MISS 31 ARKANSAS STATE 19 : Upended in ... 21 Dec 2005 Arkansas Democrat Gazette, Noce fumbled a low snap in Shotgun formation and Kevis Coley recovered at the Indians’ 10, which led to Hull’s 1-yard touchdown run to make it 17-10 with ...
sports diary: 21 Dec 2005 Daily Times, The 39-year-old former Italian international was punished after making the gesture while he was substituted in his team’s 1-1 draw against Juventus at the ...
Pinnacle Pulse - The Inside Line 12/22 21 Dec 2005 Covers, Colorado St. (San Diego County Credit Union Poinsettia Bowl). Navy enters this game with the nation’s #1 rushing offense, averaging 305.9 yards per game. ...
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Andretti Keeping It in the Family: 'I Really Want to Race Against ... 21 Dec 2005 PaddockTalk ...with Eddie Jones taking over the engineering duties for Marco, Barry Green running Michael’s Indy and set-up guru Tony Cicale engineering Michael’s #1 car. ...
Jenkins career-best leads Cards to win 21 Dec 2005 InsideTheVille.com (subscription), ...in the win. “I just talked with him,� Pitino said of Dean’s 1-for-5 shooting performance in the second half. “He doesn't ...
Tronox Announces Increases in Titanium Dioxide Pigment Price 21 Dec 2005 PR Newswire (press release), ...trade and regulatory matters, general economic conditions, and other factors and risks identified in Tronox's registration statement on Form S-1, which has ...
Money Mailer Announces Children's Miracle Network Partnership 21 Dec 2005 Franchise Wire (press release), Money Mailer, Entrepreneur Magazine’s #1 advertising service/direct mail franchise for 2005, is a quality leader in the $55 billion direct mail industry. ...
Liberty boys win league tournament 21 Dec 2005 Pratt Tribune, The Greenbacks also struggled against Kennedy’s 1-3-1 defense and fell behind in the first half, trailing 17-12 at the break. ...
Redington Beach promotes 'simple' traffic safety measures 21 Dec 2005 Tampa Bay Newspapers, ...said. Queen said the medians that divide North Redington Beach’s 1-mile length of Gulf Boulevard serve to protect the pedestrian. ...
Buy It Later.com 21 Dec 2005 MSNBC The company had raised more than $140 million at the time. Looking over the company's S-1 filing, I see that it currently has negative working capital. ...
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Integrated Electrical Services Announces Date of Earnings Release ... 21 Dec 2005 MSN Money If the company is unable to cause its previously filed S-1 in support of the Senior Convertible Notes to become effective, penalty interest may apply under ...
Eagle Test Systems Files New IPO, For $115 Million In Cmn Stock 21 Dec 2005 Business Online, ...filed an initial public offering Tuesday to sell up to $115 million in common stock, according to an original form S-1 filed with the Securities and Exchange ...
Cardica Sets IPO At 3.5 Million Common Shares, $12-$14/Share 21 Dec 2005 Business Online, The underwriters also may purchase up to 525,000 additional shares to cover overallotments, according to amended Form S-1 filed Tuesday with the Securities and ...
Donors Underwrite DeLay‘s Deluxe Lifestyle 21 Dec 2005 Herald News Daily, By LARRY MARGASAK and SHARON THEIMER, s 1 minute ago. WASHINGTON - As Tom DeLay became a king of campaign fundraising, he lived like one too. ...
Series S-1 Income Fund Announces Distribution Dec 19, 2005 CCNMatthews (Communiqués de presse), 19, 2005) - Series S-1 Income Fund (TSX:SRC.UN) reports the distribution to unitholders of record at the close of business on December 31, 2005 and payable on ...
- By Our Correspondent Dec 20, 2005 The Asian Age, 1600 m: Bribe N Prejudice (Laxman) Yousnooze Youloose (Arvind Joshi) 1-49. Gate practice: 1200 m: Portfolio (Suresh) Pure and Simple (Ravinder S) 1-19. ...
Snohomish wins fourth straight meet Dec 14, 2005 Snohomish Herald, 200 freestyle-Lewis (S) 2:10.96; 200 individual medley-Kim (S) 2:24.57; 50 freestyle-Crooks (S) 23.99; Diving-Not held; 100 butterfly-Kim (S) 1:00.55; 100 ...
Citadel S-1 Income Trust Fund: 3rd Quarter Report 2005 Nov 25, 2005 CCNMatthews (press release), For the quarter ended September 30, 2005, Citadel S-1 produced a positive 2.5% total return on a unit price basis and a 4.1% total return on a net asset value ...
Citadel Stable S-1 Income Fund: 3rd Quarter Report 2005 Nov 25, 2005 CCNMatthews (press release), For the quarter ended September 30, 2005, Citadel Stable S-1 had a negative 0.6% total return on a unit price basis and a positive 6.0% total return on a net ...
Citadel S-1 Announces Distribution and Top Ten Holdings Nov 22, 2005 CCNMatthews (press release), 22, 2005) - Citadel S-1 Income Trust Fund (TSX:SDL.UN) reports the distribution to unitholders of record at the close of business on November 30, 2005 and ...
World’s #1 Greatest Hitman Evar Nov 19, 2005 PSX2, Think you can attain such a prestigious title? Hitman: Blood Money will have you proving it soon enough. Online, no less! Assuming ...
MISCOR Group, Ltd. Announces Filing of S-1 Registration Nov 28, 2005 Yahoo! News (press release) ...large diesel engines and the construction industry, announced today that the company filed on October 31, 2005 a Registration Statement on Form S-1 with the US ...
Real Estate Insiders: America’s #1 Real Estate Radio Show to Air ... Dec 3, 2005 Emediawire (press release), Radio show offers mortgage and real estate advice to millions, will air live in Chicago. Livonia, MI (PRWEB) December 3, 2005 -- Beginning on Dec. ...
Real Estate Insiders: America’s #1 Real Estate Radio Show to Air ... Dec 3, 2005 PR Web (press release), Radio show offers mortgage and real estate advice to millions, will air live in Chicago. Livonia, MI (PRWEB via PR Web Direct) December ...
IntraLinks Withdraws S-1 Filing Nov 21, 2005 dBusinessNews New York (press release), NEW YORK -- IntraLinks, a leading provider of secure online workspaces to businesses worldwide, today announced that it has decided not to pursue its initial ...
India’s #1 Telco planning US$11 a month PC-broadband combo Nov 22, 2005 DMasia.com, Bharat Sanchar Nigam, India's largest telecom company, is planning to roll out an offer later this month that will bundle a PC with a broadband connection for ...
Kamiak uses its depth to beat EW Dec 16, 2005 Lynwood Herald, S) 56.00; 100 freestyle-Murphy (S) 56.43; 500 freestyle-Chien (S) 5:22.71; 200 freestyle relay-Shorecrest 1:46.22; 100 backstroke-Zylstra (S) 1:08.86; 100 ...
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