MS-275
information and resources from the National Cancer Institute
NCI Thesaurus | MS-275
A synthetic benzamide derivative. MS-275 binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. MS-275 appears to exert dose-dependent effects in human leukemia cells including p21(CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. p21(CIP1/WAF1) is an inhibitor of cyclin-dependent kinases; in normal cells, its expression has been associated with cell-cycle exit and differentiation. NCI Thesaurus | MS-275
A synthetic benzamide derivative. MS-275 binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. MS-275 appears to exert dose-dependent effects in human leukemia cells including p21(CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. p21(CIP1/WAF1) is an inhibitor of cyclin-dependent kinases; in normal cells, its expression has been associated with cell-cycle exit and differentiation.
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news articles
Histone Deacetylase Inhibitor Pharmacodynamic Analysis by ... Oct 29, 2005
Annals of Clinical & Laboratory Science, ...and then tested in peripheral blood of solid tumor patients and in bone marrow aspirates of leukemia patients on phase I trials of the HDAC inhibitor MS-275. ...
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