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Lysodren
Lysodren
information and resources from the National Cancer Institute
Lysodren
(Other name for: mitotane)mafosfamide
A synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis. Lysodren
(Other name for: mitotane)
mitotane Bristol-Myers Squibb Jul 08 1970
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Lysodren
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