Hypericum perforatum
information and resources from the National Cancer Institute
NCI Thesaurus | Hypericum perforatum
An herbal preparation isolated from the plant St. John's Wort with photodynamic, antineoplastic, and antidepressant properties. Hypericin, one of the active compounds found in hypericum perforatum, is a photosensitizer that, when exposed to a particular wavelength and intensity of light, may induce tumor cell apoptosis. Another compound, hyperforin, induces caspase-dependent apoptosis in certain tumor cell lines. Hypericum perforatum preparations may also stimulate the activity of cytochrome P450 enzymes and P-glycoprotein drug transporters, resulting in increased metabolism and decreased efficacy of various chemotherapeutic agents and other drugs. NCI Thesaurus | Hypericum perforatum
An herbal preparation isolated from the plant St. John's Wort with photodynamic, antineoplastic, and antidepressant properties. Hypericin, one of the active compounds found in hypericum perforatum, is a photosensitizer that, when exposed to a particular wavelength and intensity of light, may induce tumor cell apoptosis. Another compound, hyperforin, induces caspase-dependent apoptosis in certain tumor cell lines. Hypericum perforatum preparations may also stimulate the activity of cytochrome P450 enzymes and P-glycoprotein drug transporters, resulting in increased metabolism and decreased efficacy of various chemotherapeutic agents and other drugs.
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news articles
St John's Wort Benefits and Side Effects Mar 7, 2006
DailyIndia.com, ...by Chester Ku-Lea. Extracts of Hypericum perforatum L. (St John's wort) are now successfully competing for status as a standard antidepressant therapy. ...
ABBOTT STATEMENT ON ADVANCING PEDIATRIC HIV TREATMENT IN ... Mar 13, 2006
ITNews, Mevacor(R), Zocor(R) or products containing St. John's wort (Hypericum perforatum). Once-daily lopinavir/ritonavir should not be ...
Abbott Statement on Advancing Pediatric HIV Treatment in ... Mar 13, 2006
Yahoo! News (press release) Flonase®, Mevacor®, Zocor® or products containing St. John's wort (Hypericum perforatum). Once- daily lopinavir/ritonavir should not ...
Hyperforin Plasma Level Inconsistency Found in 2002 St. John’s ... Dec 12, 2005
NPIcenter (press release), John’s wort (Hypericum perforatum) and major depression that had been published in the Journal of the American Medical Association (JAMA) over 3 years earlier ...
Shandong Province Government Submits Fast Track Application for ... Nov 29, 2005
Market Wire (press release) The result showed hypericin, which is isolated from hypericum perforatum, had cured all poultry infected by the deadly H5N1 avian flu for the experiment. ...
Diseases of Dietary Origin Nov 24, 2005
TheHorse.com, Two main plants are culprits in this situation: St. John's wort (Hypericum perforatum) and buckwheat (Fagopyrum esculentum). Other ...
New Data Show a Kaletra(R) (Lopinavir/Ritonavir)-Based Regimen ... Nov 18, 2005
Yahoo! News (press release) John's Wort (Hypericum perforatum). Particular caution should be used when taking Kaletra with sildenafil, tadalafil or vardenafil. ...
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