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FR901228
FR901228
information and resources from the National Cancer Institute
NCI Thesaurus | FR901228
A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum. After intracellular activation, depsipeptide binds to and inhibits histone deacetylase, thereby affecting the regulation of gene expression and inducing cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia-induced angiogenesis and depletes several HSP90-dependent oncoproteins.NCI Thesaurus | FR901228
A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum. After intracellular activation, depsipeptide binds to and inhibits histone deacetylase, thereby affecting the regulation of gene expression and inducing cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia-induced angiogenesis and depletes several HSP90-dependent oncoproteins.
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FR901228
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