E7389

E7389 information and resources from the National Cancer Institute

E7389

A synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. E7389 binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.

Eisai plans research center Mar 4, 2006
NorthJersey.com, Nearest to market is the breast cancer drug E7389, a synthetic chemical developed by Eisai scientists to mimic the active ingredient found in an obscure sea ...

Oncology pipeline drives Eisai’s expansion Mar 6, 2006
In-PharmaTechnologist.com, Pushing the latest expansion are a number of cancer drugs in Eisai's pipeline, with the most advanced being E7389 for the treatment of advanced, refractory ...

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