DOXIL
information and resources from the National Cancer Institute
DOXIL
(Other name for: doxorubicin HCl liposome)doxorubicin
An anthracycline antineoplastic antibiotic isolated from the fungus Streptococcus peucetius var. caesius. Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. The hydrochloride salt doxorubicin hydrochloride is the therapeutic form of doxorubicin. DOXIL
(Other name for: doxorubicin HCl liposome)
NCI Thesaurus | Doxil
(Other name for: pegylated doxorubicin HCl liposome)NCI Thesaurus | Doxil
(Other name for: pegylated doxorubicin HCl liposome)
doxorubicin liposomal
Accel. Approv. (clinical benefit not established) Treatment of AIDS-related Kaposi's sarcoma in patients with disease that has progressed on prior combination chemotherapy or in patients who are intolerant to such therapy.
Sequus Pharmaceuticals, Inc. Nov 17 1995
doxorubicin liposomal
Accel. Approv. (clinical benefit not established) Treatment of metastatic carcinoma of the ovary in patient with disease that is refractory to both paclitaxel and platinum based regimens
Sequus Pharmaceuticals, Inc. Jun 28 1999
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