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CI-1033
CI-1033
information and resources from the National Cancer Institute
NCI Thesaurus | CI-1033
An orally bioavailable quinazoline with potential antineoplastic and radiosensitizing activities. CI-1033 binds to the intracellular domains of pan-erbB tyrosine kinases, irreversibly inhibiting their signal transduction functions and resulting in apoptosis and suppression of tumor cell proliferation. erbB is a member of the epidermal growth factor receptor (EGFR) family and is implicated in the malignant transformation of many solid tumors, including breast, ovarian, prostate, lung, and brain cancers. CI-1033 also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents. NCI Thesaurus | CI-1033
An orally bioavailable quinazoline with potential antineoplastic and radiosensitizing activities. CI-1033 binds to the intracellular domains of pan-erbB tyrosine kinases, irreversibly inhibiting their signal transduction functions and resulting in apoptosis and suppression of tumor cell proliferation. erbB is a member of the epidermal growth factor receptor (EGFR) family and is implicated in the malignant transformation of many solid tumors, including breast, ovarian, prostate, lung, and brain cancers. CI-1033 also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents.
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CI-1033
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