|
AE-941
AE-941
information and resources from the National Cancer Institute
AE-941
A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Neovastat competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cell receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells.
|
|
|
|
|
|
AE-941
-->
|
