17-dimethylaminoethylamino-17-demethoxygeldanamycin
information and resources from the National Cancer Institute
NCI Thesaurus | 17-dimethylaminoethylamino-17-demethoxygeldanamycin
An analogue of the benzoquinone antineoplastic antibiotic geldanamycin. 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. NCI Thesaurus | 17-dimethylaminoethylamino-17-demethoxygeldanamycin
An analogue of the benzoquinone antineoplastic antibiotic geldanamycin. 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
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news articles
Keryx Biopharmaceuticals, Inc. Announces Oral Presentation on KRX ... Dec 8, 2005
PR Newswire (press release), Kenneth C. Anderson * 1592 Combination of the AKT Inhibitor Perifosine with the HSP90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin (17-DMAG ...
Keryx Biopharmaceuticals, Inc. Announces Oral Presentation on KRX ... Dec 8, 2005
PharmaLive.com (press release), 1592 Combination of the AKT Inhibitor Perifosine with the HSP90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin (17-DMAG) Has Synergistic ...
Keryx Biopharmaceuticals, Inc. Announces Oral Presentation on KRX ... Dec 8, 2005
PR Newswire (press release), Kenneth C. Anderson * 1592 Combination of the AKT Inhibitor Perifosine with the HSP90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin (17-DMAG ...
Keryx Biopharmaceuticals, Inc. Announces Oral Presentation on KRX ... Dec 8, 2005
PharmaLive.com (press release), 1592 Combination of the AKT Inhibitor Perifosine with the HSP90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin (17-DMAG) Has Synergistic ...
17-dimethylaminoethylamino-17-demethoxygeldanamycin
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