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17-N-allylamino-17-demethoxygeldanamycin
17-N-allylamino-17-demethoxygeldanamycin
information and resources from the National Cancer Institute
NCI Thesaurus | 17-N-allylamino-17-demethoxygeldanamycin
A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. 17-allylamino 17-demethoxygeldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells. NCI Thesaurus | 17-N-allylamino-17-demethoxygeldanamycin
A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. 17-allylamino 17-demethoxygeldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells.
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17-N-allylamino-17-demethoxygeldanamycin
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