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Polycythemia vera
Tamaqua considering Mar 12, 2006
Allentown Morning Call, ...in drinking water that cause cancer and other illnesses and the number of residents who say they have a rare disease called polycythemia vera, which causes the ...
LTA sponsors fundraiser for Clarkston girl on Saturday Mar 7, 2006
Lewis-Clark State College, ...this Saturday for Scarlett Crutchfield, a 12-year-old girl from Clarkston who was recently diagnosed with a rare pre-leukemia condition called polycythemia vera ...
Amarillo Biosciences Issues Progress Report Feb 14, 2006
Market Wire (press release) Center in Houston, Texas, to evaluate interferon lozenges in patients with the pre-leukemic conditions known as essential thrombocythemia and polycythemia vera ...
Phoenix news briefs Feb 15, 2006
Arizona Republic, Adrienne Padnick suffers from a rare blood disease known as polycythemia vera, which causes excess production of red blood cells in her bone marrow. ...
Eustis High coach recovering at Mayo Feb 18, 2006
Orlando Sentinel, ...major-league player who spent 18 years with the Detroit Tigers and Chicago White Sox, suffers from an incurable and rare disorder called polycythemia vera. ...
Eustis High baseball coach is hospitalized Feb 17, 2006
Orlando Sentinel, Lemon was diagnosed in 1990 with polycythemia vera, an incurable and rare disorder that causes the bone marrow to produce an overabundance of red blood cells ...
More water testing sought Jan 24, 2006
Allentown Morning Call, Results released last week found that the rare cancer polycythemia vera, which thickens the blood, is no more prevalent in Schuylkill, Carbon and Luzerne ...
Rush cancer isn't higher, study finds Jan 19, 2006
Allentown Morning Call, In fact, the rate of polycythemia vera, a disease that thickens the blood, is higher in Luzerne County than in Rush Township, the study found. ...
Cancer Study Unveiled in Schuylkill County Jan 18, 2006
WNEP-TV, Les and Betty suffer from a rare form of blood cancer, polycythemia vera . Their doctor has told them the chances of a couple having it is one in a million. ...
Butcher focuses on the positive Dec 31, 2005
Fairbanks Daily News-Miner, ...school.". Butcher was diagnosed in 2002 with polycythemia vera, a form of cancer that attacks the stem cells in the bone marrow. ...
Changing portraits of Susan Butcher Dec 26, 2005
Anchorage Daily News, Butcher disclosed earlier this month that she also has a rare bone marrow disorder, polycythemia vera, and has been undergoing treatment the past three years. ...
Iditarod champion Susan Butcher being treated for leukemia Jan 2, 2006
kgw.com (subscription), ...said. Several years ago, Butcher was diagnosed with polycythemia vera, a less aggressive cancer affecting the bone marrow. About ...
Sled-dog champ fights leukemia Dec 20, 2005
Minneapolis Star Tribune (subscription), For the previous three years, Butcher had been undergoing treatment for polycythemia vera, a rare bone marrow disorder that causes overproduction of blood cells ...
Discoveries Reveal Gene Mutation That Causes Blood Disorders Dec 11, 2005
PR Newswire (press release), ...of blood cells. The three main MPDs are polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis. The actual incidence ...
Researchers Closer to Understanding How One Mutation Causes Three ... Dec 19, 2005
Howard Hughes Medical Institute, The first, polycythemia vera, involves ultra-high red blood cell counts. The second, essential thrombocytopenia, results from excess growth of blood platelets. ...
Susan Butcher's Race for Life Dec 14, 2005
New York Times, For three years, she battled polycythemia vera - a bone-marrow disease that results in an abnormal increase in red-blood cells. ...
Musher says she will beat cancer Dec 9, 2005
Anchorage Daily News, For the previous three years, Butcher had been under treatment for polycythemia vera, a rare bone marrow disorder that causes overproduction of blood cells. ...
Four-time Iditarod champion fighting cancer Dec 9, 2005
kgw.com (subscription), Three years ago, when she was considering a comeback, doctors found Butcher had polycythemia vera, a rare disease that causes the bone marrow to produce excess ...
'My whole life has been about challenges' Dec 10, 2005
Fairbanks Daily News-Miner, Butcher said she was first diagnosed with polycythemia vera, a disorder that causes the body to produce too many red blood cells, while she was preparing to ...
Source: Quest Diagnostics Incorporated Dec 9, 2005
Yahoo! News (press release) ...the most common genomic abnormality in myeloproliferative diseases involving blood cells derived from bone marrow (polycythemia vera, essential thrombocythemia ...
Amarillo Biosciences CEO Dr. Joseph Cummins Interviewed by Wall ... Dec 12, 2005
Market Wire (press release) ...companies and research centers to test the efficacy of low dose oral interferon on pulmonary fibrosis, Behcet's disease, polycythemia vera and essential ...
Wildcats' Elliott still has desire for big-time job Nov 3, 2005
DesMoinesRegister.com, ...coordinator, Elliott would have been a serious candidate to replace Hayden Fry after the 1998 season had he not developed polycythemia vera , a cancer ...
Rare cancer makes contact with water painful Oct 31, 2005
London Free Press, ...to the cancer centre in London. There, he was diagnosed with a form of bone marrow cancer, polycythemia vera. He was put on daily ...
Primary polycythemia, often called polycythemia vera (PCV), polycythemia rubra vera (PRV), erythremia, or just PV, occurs when excess erythrocytes are produced as a result of a proliferative abnormality of the bone marrow. Often, excess white blood cells (leukocytosis) and platelets (thrombocytosis) are also produced. It is, therefore, classified as a myeloproliferative disease.
In primary polycythemia there may be 8 to 9 million and occasionally 11 million erythrocytes per cubic millimeter of blood, and the hematocrit may be as high as 70 to 80%. In addition, the total blood volume sometimes increases to as much as twice normal. The entire vascular system can become markedly engorged with blood, and circulation times for blood throughout the body can increase up to twice the normal value. The increased numbers of erythrocytes can increase the viscosity of the blood to as much as five times normal. Capillaries can become plugged by the very viscous blood, and the flow of blood through the vessels tends to be extremely sluggish.
As a consequence of the above, people with untreated PV are at a risk of various thrombotic events (deep venous thrombosis, pulmonary embolism), heart attack and stroke, and have a substantial risk of Budd-Chiari syndrome (hepatic vein thrombosis). The condition is considered chronic; no cure exists. Symptomatic treatment (see below) can normalize the blood count and most patients can live a normal life for years.
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