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Pituitary Cancer
Giambi in line for his reward -- Sep 14, 2005
But he's also come back from adversity and misery he created. There's no evidence of a link between performance enhancers and pituitary cancer. ... / Albany Times Union,
Pituitary adenomas are tumors that occur in the pituitary gland, and account for about 10% of intracranial neoplasms. They often remain undiagnosed, and small pituitary tumors are found in 6 to 24 percent of adults at autopsy.
Pituitary tumors were, historically, classed as basophilic, acidophilic, or chromophobic on the basis of whether or not they took up the stains hematoxylin and eosin. This classification has fallen into disuse, in favor of a classification based on what type of hormone is secreted by the tumor (though tumors which do not secrete any active hormone ("non-functioning tumors") are still sometimes called "chromophobic").
At present, classification of pituitary tumors is based on plasma hormone levels or immunohistochemical staining:- corticotrophic adenomas secrete adrenocorticotropic hormone (ACTH) and pro-opiomelanocortin (POMC)
- somatotrophic adenomas secrete growth hormone (GH)
- thyrotrophic adenomas secrete thyroid-stimulating hormone (TSH)
- This is a rare tumor type, making up <1% of all pituitary adenomas. TSH secretion from these tumors can cause hyperthroidism.[1]
- gonadotrophic adenomas secrete luteinizing hormone (LH), follicle-stimulating hormone (FSH) and their subunits
- lactrotrophic adenomas or prolactinomas secrete prolactin
- null cell adenomas do not secrete hormones, but may stain positive for synaptophysin
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