|
|
|
|
Myeloproliferative disease
Researchers Closer to Understanding How One Mutation Causes Three ... Dec 19, 2005
Howard Hughes Medical Institute, The discovery “provides new and important insights into how this gene contributes to the development of myeloproliferative disease,� said D. Gary Gilliland ...
The myeloproliferative diseases are a group of diseases of the bone marrow where excess cells are produced. The delineation from leukemia is artificial, although the myeloproliferative diseases on the whole have a much better prognosis than the leukemias. The concept was first proposed in 1951 by the eminent hematologist William Dameshek.
The myeloproliferative diseases are:- Chronic myelogenous leukemia (CML)
- Polycythemia vera (PCV)
- Essential thrombocytosis (ET)
- Myelofibrosis (increased connective tissue with decreased room for production of normal blood cells).
All MPDs arise from precursors of the "myeloid" lineage in the bone marrow. The lymphoid lineage may produce similar diseases, the lymphoproliferative disorders (acute lymphoblastic leukemia, lymphomas, chronic lymphocytic leukemia and multiple myeloma).
|
|
|
