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    Li-Fraumeni Syndrome





    Skeletons in the p53 tumor suppressor closet: genetic evidence ... 14 Mar 2006
    Journal of Cell Biology The latter situation is referred to as Li-Fraumeni syndrome, which is characterized by a predisposition to diverse tumor types, including osteosarcomas. ...

    a child's last days -- Jun 20, 2005
    Last year, doctors diagnosed Courtney with a rare genetic disorder, Li-Fraumeni syndrome, which predisposes her to different types of cancer. ... / Kentucky.com,

    Hand in hand, it's a family triumph -- Jun 6, 2005
    The McGurrell family suffer from a genetic condition known as Li-Fraumeni's syndrome[correct], which affects only 400 families in the world and increases their ... / ic Teesside.co.uk,



    Genome-wide Mouse Study Yields Link To Human Leukemia -- Feb 24, 2005
    December 31, 2004) -- Scientists from MIT's Center for Cancer Research have developed a new mouse model that closely resembles Li-Fraumeni Syndrome (LFS) in ... / Science Daily (press release)


    Genome-wide Mouse Study Yields Link To Human Leukemia Feb 24, 2005
    December 31, 2004) -- Scientists from MIT's Center for Cancer Research have developed a new mouse model that closely resembles Li-Fraumeni Syndrome (LFS) in ... Science Daily

    COURTNEY'S PRAYER Nov 17, 2004
    Without Li-Fraumeni syndrome, Courtney would have had just a 10 percent to 20 percent chance of survival, even after undergoing a bone marrow transplant. ... Lexington Herald Leader

    Childhood Cancer: Osteosarcoma Nov 12, 2004
    Also, children who have inherited one of the rare "cancer syndromes," such as retinoblastoma or Li-Fraumeni syndrome, have a higher risk for osteosarcoma. ... Yahoo News


    Mother says goodbye to loved ones -- Oct 16, 2004
    Ms Dick's family is one of about 400 in the world that carry the deadly burden of Li-Fraumeni syndrome, a genetic mutation on chromosome 17 known as P53. ... / Tasmania Examiner,

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    Li-Fraumeni syndrome is a rare autosomal dominant hereditary disorder. It is named after Frederick Pei Li and Joseph F. Fraumeni, American physicians who originally described the syndrome. It increases greatly the susceptibility to cancer. The syndrome is a mutation in the p53 tumor suppressor gene, which normally helps control cell growth.

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